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RHBDF2 Knockout Cell Lines

Gene: RHBDF2

Official Full Name: rhomboid 5 homolog 2provided by HGNC

Gene Summary: Predicted to enable protein transporter activity. Predicted to be involved in negative regulation of protein secretion and regulation of epidermal growth factor receptor signaling pathway. Predicted to act upstream of or within protein localization to plasma membrane and regulation of metalloendopeptidase activity. Located in plasma membrane. Implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14562 RHBDF2 Knockout cell line (HeLa) Human RHBDF2 1:3~1:6 Negative Online Inquiry
KO14563 RHBDF2 Knockout cell line (HCT 116) Human RHBDF2 1:2~1:4 Negative Online Inquiry
KO14564 RHBDF2 Knockout cell line (HEK293) Human RHBDF2 1:3~1:6 Negative Online Inquiry
KO14565 RHBDF2 Knockout cell line (A549) Human RHBDF2 1:3~1:4 Negative Online Inquiry

Background

RHBDF2 Gene Knockout Cell Lines are specifically engineered cellular models used to study the RHBDF2 (Rhomboid-5 domain containing 2) gene's function by creating a loss-of-function scenario. This is accomplished through CRISPR/Cas9 technology, which precisely targets and disrupts the RHBDF2 gene, allowing researchers to investigate its role in cellular processes, particularly those associated with signal transduction and membrane dynamics.

The primary function of the RHBDF2 knockout cell lines is to enable researchers to elucidate the cellular mechanisms influenced by RHBDF2, as well as its potential involvement in various pathological conditions, including cancer and neurodegenerative diseases. By assessing the phenotypic and molecular changes that occur following the gene's knockout, scientists can gain insights into the signaling pathways regulated by RHBDF2, thus facilitating the development of targeted therapies.

These cell lines represent a significant advancement in biological research due to their ability to provide a clearer understanding of gene function in a controlled setting. They are invaluable in both fundamental research and clinical applications, serving as models for drug discovery and toxicology studies, which are essential for therapeutic development.

In comparison to traditional knockout methods, RHBDF2 Gene Knockout Cell Lines offer enhanced efficiency, precision, and reproducibility. The CRISPR-based approach allows for rapid generation of stable cell lines, ultimately saving time and resources in experimental design and implementation.

The RHBDF2 Gene Knockout Cell Lines are a high-quality product that brings exceptional value to researchers and clinicians seeking to deepen their understanding of gene function and related diseases. Backed by our company's expertise in gene editing technologies and cell line development, we are committed to providing cutting-edge resources that empower scientific innovation and contribute to advancements in healthcare.

Please note that all services are for research use only. Not intended for any clinical use.

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