Gene: RETREG1
Official Full Name: reticulophagy regulator 1provided by HGNC
Gene Summary: The protein encoded by this gene is a cis-Golgi transmembrane protein that may be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Mutations in this gene are a cause of hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), and this gene may also play a role in susceptibility to vascular dementia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00014 | RETREG1 Knockout cell line (Huh-7) | Human | RETREG1 | 1:2~1:3 | Negative | Online Inquiry |
KO00546 | RETREG1 knockout cell line (A549) | Human | RETREG1 | 1:3~1:4 | Negative | Online Inquiry |
KO09729 | RETREG1 Knockout cell line (HeLa) | Human | RETREG1 | 1:3~1:6 | Negative | Online Inquiry |
KO09730 | RETREG1 Knockout cell line (HCT 116) | Human | RETREG1 | 1:2~1:4 | Negative | Online Inquiry |
KO09731 | RETREG1 Knockout cell line (HEK293) | Human | RETREG1 | 1:3~1:6 | Negative | Online Inquiry |
RETREG1 Gene Knockout Cell Lines are specialized cellular models that have been engineered through the targeted disruption of the RETREG1 gene. This gene encodes a protein involved in various cellular processes, including stress responses, protein degradation, and endocytic trafficking. By creating knockout cell lines, researchers can effectively study the loss-of-function effects associated with RETREG1, providing insights into its biological role and potential implications in disease mechanisms.
The primary function of these cell lines is to serve as a valuable tool for elucidating the physiological and pathological roles of the RETREG1 gene. The knockout mechanism allows for the systematic examination of altered cellular behaviors, which can manifest in diverse areas such as metabolic regulation, immune response, and cellular signaling pathways. By employing these models, researchers can investigate RETREG1’s role in various conditions, including cancer, neurodegenerative diseases, and metabolic disorders.
The scientific importance of RETREG1 Gene Knockout Cell Lines lies in their applicability in both foundational research and translational medicine. In a laboratory setting, these cell lines provide a straightforward approach for studying gene function and cellular processes. In clinical applications, they might help illuminate the underlying mechanisms of diseases where RETREG1 is implicated, thus paving the way for novel therapeutic interventions or biomarker development.
RETREG1 Gene Knockout Cell Lines offer distinct advantages over alternative models, such as primary cells or transiently transfected systems, by providing stable and reproducible conditions for experimentation. These knockout lines facilitate long-term studies and minimize the variability typically associated with primary cell cultures. Furthermore, their generation and maintenance are streamlined, allowing researchers to focus on data generation rather than technical challenges.
For researchers and clinicians aiming to explore gene function, disease pathways, or therapeutic targets, RETREG1 Gene Knockout Cell Lines represent an essential resource. Their availability enhances experimental reproducibility and depth, leading to more robust and meaningful scientific outcomes. Our company, with extensive expertise in genomic technologies and cell line development, is committed to providing high-quality biological products that support innovation in research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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