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RELT Knockout Cell Lines

Gene: RELT

Official Full Name: RELT TNF receptorprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24400 RELT Knockout cell line (HeLa) Human RELT 1:3~1:6 Negative Online Inquiry
KO24401 RELT Knockout cell line (HCT 116) Human RELT 1:2~1:4 Negative Online Inquiry
KO24402 RELT Knockout cell line (HEK293) Human RELT 1:3~1:6 Negative Online Inquiry
KO24403 RELT Knockout cell line (A549) Human RELT 1:3~1:4 Negative Online Inquiry

Background

RELT Gene Knockout Cell Lines are advanced biological tools designed to facilitate the study of gene function through targeted gene disruption. These cell lines have been meticulously engineered to possess specific deletions in the RELT gene, a member of the TNF receptor superfamily, known to play a pivotal role in various cellular processes such as apoptosis, immune response, and signal transduction. The knockout mechanism is achieved using CRISPR/Cas9 technology, ensuring precise and efficient gene editing, resulting in a reliable model to assess the biological consequences of RELT deficiency.

The primary function of the RELT Gene Knockout Cell Lines lies in their ability to help researchers elucidate the role of the RELT gene in pathological conditions, such as inflammation and cancer. By observing changes in cellular behavior, signal pathways, and gene expression profiles, scientists can gain critical insights into the underlying mechanisms of diseases associated with RELT dysregulation. These cell lines also serve as an essential resource in drug discovery and development, allowing for the screening of therapeutic compounds targeting the RELT pathway.

One significant advantage of RELT Gene Knockout Cell Lines over traditional models is their specificity and reproducibility. Unlike transient knockdown strategies, which provide only temporary gene silencing, our knockout cell lines induce stable and heritable gene disruption. This stability results in consistent experimental outcomes, reducing variability and enhancing data reliability. Furthermore, they provide a versatile platform for co-culture experiments, enabling comprehensive studies of cellular interactions within tumor microenvironments or immune responses.

For researchers and clinicians aiming to understand the complexities of gene behavior in relevant biological contexts, RELT Gene Knockout Cell Lines represent an invaluable asset. Their cutting-edge design, coupled with the promise of enhancing disease understanding and therapeutic innovation, positions them as a crucial addition to any research portfolio.

Our company, specializing in the creation of high-quality, precision-engineered biological products, stands firmly committed to supporting advancements in the life sciences. We seamlessly combine innovative technologies with scientific expertise, ensuring our customers have the best resources at their disposal for impactful research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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