Gene: RBM5
Official Full Name: RNA binding motif protein 5provided by HGNC
Gene Summary: This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32188 | RBM5 Knockout cell line (HeLa) | Human | RBM5 | 1:3~1:6 | Negative | Online Inquiry |
KO32189 | RBM5 Knockout cell line (HCT 116) | Human | RBM5 | 1:2~1:4 | Negative | Online Inquiry |
KO32190 | RBM5 Knockout cell line (HEK293) | Human | RBM5 | 1:3~1:6 | Negative | Online Inquiry |
KO32191 | RBM5 Knockout cell line (A549) | Human | RBM5 | 1:3~1:4 | Negative | Online Inquiry |
RBM5 Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the study of the RBM5 gene's functions in cellular and molecular processes. RBM5, or RNA Binding Motif Protein 5, plays a critical role in the regulation of alternative splicing, mRNA stability, and gene expression. By utilizing CRISPR-Cas9 technology, these knockout cell lines have been meticulously developed to silence the RBM5 gene, enabling researchers to analyze the effects of its absence on cellular behavior, signaling pathways, and gene regulatory networks.
The primary mechanism of RBM5 involves its interaction with various RNA species, thus influencing transcriptional and post-transcriptional processes. The knockout of this gene allows for the exploration of its role in diseases, particularly in cancer pathology, where alternative splicing plays a pivotal role in tumor progression. By studying these cell lines, scientists can uncover critical insights into how the loss of RBM5 contributes to oncogenesis and identify potential therapeutic targets.
In research and clinical applications, RBM5 Gene Knockout Cell Lines provide unparalleled advantages over traditional methods. They offer a precise, reproducible model that captures the biological variances associated with RBM5 deficiency, enabling a deeper understanding of related cellular responses. Unlike conventional knockdown approaches, which may leave residual protein activity, complete knockout eliminates any confounding results, thereby enhancing the reliability of experimental outcomes.
For researchers and clinicians, the value of these cell lines extends beyond basic research; they serve as a crucial tool for drug discovery and development, allowing for the evaluation of therapeutic efficacy in RBM5-mediated pathways. Furthermore, their robustness and functional versatility make them suitable for a wide range of experiments, from mechanistic studies to high-throughput screening.
Our company specializes in providing high-quality, validated biological products such as the RBM5 Gene Knockout Cell Lines, backed by extensive research and development efforts. With our dedication to scientific excellence, we empower researchers to advance their work and drive innovation within the fields of molecular biology and genetics.
Please note that all services are for research use only. Not intended for any clinical use.
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