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RBM45 Knockout Cell Lines

Gene: RBM45

Official Full Name: RNA binding motif protein 45provided by HGNC

Gene Summary: This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26653 RBM45 Knockout cell line (HeLa) Human RBM45 1:3~1:6 Negative Online Inquiry
KO26654 RBM45 Knockout cell line (HCT 116) Human RBM45 1:2~1:4 Negative Online Inquiry
KO26655 RBM45 Knockout cell line (HEK293) Human RBM45 1:3~1:6 Negative Online Inquiry
KO26656 RBM45 Knockout cell line (A549) Human RBM45 1:3~1:4 Negative Online Inquiry

Background

RBM45 Gene Knockout Cell Lines are specially engineered cellular models designed to study the physiological and pathological roles of the RBM45 gene. This genomic alteration is achieved through homologous recombination techniques, resulting in a precise disruption of the RBM45 gene function, which is crucial for various cellular processes including RNA alternative splicing and mRNA metabolism. These knockout cell lines offer invaluable tools for examining the consequences of RBM45 deficiency in cellular function, differentiation, and response to external stimuli.

The primary mechanisms of action involve the loss of RBM45-associated regulatory functions, which allows researchers to investigate downstream effects such as gene expression alterations and signaling pathway modifications. This gene's involvement in neurodegenerative diseases and cancer further underscores the relevance of these cell lines in comprehensively understanding disease mechanisms.

In research and clinical settings, RBM45 Gene Knockout Cell Lines serve as crucial platforms for drug discovery, biomarker identification, and therapeutic target validation. By providing direct insights into the functional role of RBM45, researchers can better delineate its implications in disease progression and treatment responses, bridging translational gaps in biomedical research.

What sets our RBM45 Gene Knockout Cell Lines apart from alternatives is the precision and reproducibility of our gene-editing process, ensuring high-fidelity models that are ready for immediate application in various experimental setups. Additionally, extensive characterization and validation ensure that our cell lines reflect the biological conditions and phenotypic responses expected in vivo.

For researchers and clinicians, adopting these advanced models accelerates the pace of discovery while improving the reliability of experimental outcomes. Our company's extensive expertise in genetic engineering and cell line development positions us as a trusted provider of high-quality biological products tailored to meet the evolving needs of the scientific community. With a commitment to innovation and support, we empower our users to make significant strides in their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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