Gene: RAMP1
Official Full Name: receptor activity modifying protein 1provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32054 | RAMP1 Knockout cell line (HCT 116) | Human | RAMP1 | 1:2~1:4 | Negative | Online Inquiry |
KO32055 | RAMP1 Knockout cell line (HEK293) | Human | RAMP1 | 1:3~1:6 | Negative | Online Inquiry |
RAMP1 Gene Knockout Cell Lines are specialized cellular models developed to facilitate the study of the Receptor Activity-Modifying Protein 1 (RAMP1) gene. These engineered cell lines have been meticulously designed to lack the expression of RAMP1, providing researchers with a powerful tool to investigate the biological processes and pathways mediated by this critical protein. RAMP1 plays an essential role in modulating GPCR (G-protein coupled receptor) signaling, particularly in the context of the calcitonin gene-related peptide (CGRP) system, which is pivotal in neurological and cardiovascular functions.
By utilizing RAMP1 Gene Knockout Cell Lines, researchers can delve into the implications of RAMP1 absence on receptor functionality, signal transduction mechanisms, and potential downstream effects influencing pain signaling and vascular tone regulation. This capability is particularly relevant in both basic research and drug discovery pipelines, where understanding the role of RAMP1 can unveil novel therapeutic targets for migraine treatments and other sensory disorders.
What sets our RAMP1 Gene Knockout Cell Lines apart is their high specificity and reproducibility. Unlike traditional knockout methods which can produce off-target effects, our lines ensure a clean deletion of the RAMP1 gene, thus maintaining experimental integrity. Additionally, these cell lines are compatible with various assays and can be easily adapted to different experimental settings, providing versatility unmatched by competitor products.
The significance of our RAMP1 Gene Knockout Cell Lines extends into clinical applications as well, offering a platform for testing drug efficacy and safety in a controlled environment. This specificity not only enhances research output but also streamlines the path toward translational research, enabling clinicians to develop targeted therapies based on conclusive cellular data.
We are committed to advancing scientific inquiry through rigorous quality control and a deep understanding of cellular biochemistry. Our extensive expertise in the production of genetically modified cell lines ensures that you receive a product designed for optimal performance, meeting the dynamic needs of both researchers and clinicians alike. Choose RAMP1 Gene Knockout Cell Lines to enhance your research endeavors and drive innovation within the field of bioscience.
Please note that all services are for research use only. Not intended for any clinical use.
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