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RAD52 Knockout Cell Lines

Gene: RAD52

Official Full Name: RAD52 homolog, DNA repair proteinprovided by HGNC

Gene Summary: The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06326 RAD52 Knockout cell line (HeLa) Human RAD52 1:3~1:6 Negative Online Inquiry
KO06327 RAD52 Knockout cell line (HCT 116) Human RAD52 1:2~1:4 Negative Online Inquiry
KO06328 RAD52 Knockout cell line (HEK293) Human RAD52 1:3~1:6 Negative Online Inquiry
KO06329 RAD52 Knockout cell line (A549) Human RAD52 1:3~1:4 Negative Online Inquiry

Background

RAD52 Gene Knockout Cell Lines are genetically engineered cell lines where the RAD52 gene has been specifically disrupted, thereby enabling researchers to investigate the gene's functional role in DNA repair mechanisms and its implications in genomic stability. This product is essential for studying the RAD52 protein's involvement in homologous recombination, a critical pathway for repairing DNA double-strand breaks, a common form of genetic damage that can lead to cancer and other diseases if not correctly repaired.

The primary function of these knockout cell lines is to elucidate RAD52's contribution to DNA damage response and repair. By studying cells devoid of functional RAD52, researchers can observe how the absence of this protein affects cellular responses to DNA insults, such as ionizing radiation or chemotherapy, shedding light on potential vulnerabilities in cancer cells that could be exploited in therapeutic settings.

The scientific significance of the RAD52 Gene Knockout Cell Lines extends to multiple research areas, including cancer biology, genetics, and molecular diagnostics. These cell lines serve as invaluable tools for drug discovery, enabling researchers to evaluate new therapeutic agents targeting DNA repair pathways. Additionally, they provide a model for understanding genomic instability, which plays a crucial role in the development and progression of various malignancies.

One of the unique selling points of our RAD52 Gene Knockout Cell Lines is their superior reliability and robustness compared to traditional models, such as wild-type cell lines or artificially edited cells with less precise gene editing techniques. Our knockout lines are rigorously validated for the lack of RAD52 expression, ensuring that experimental results are both accurate and reproducible, providing greater confidence in data interpretation.

For researchers and clinicians alike, these cell lines are a catalyst for groundbreaking discoveries, as they open the door to novel insights into human disease mechanisms and potential therapeutic strategies. Investing in RAD52 Gene Knockout Cell Lines means equipping your laboratory with the tools necessary to advance your research in DNA repair and cancer therapy.

Our company prides itself on its commitment to quality and innovation in biological products, continually striving to provide researchers with the most precise and usable tools for their studies.

Please note that all services are for research use only. Not intended for any clinical use.

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