Gene: RAD23A
Official Full Name: RAD23 homolog A, nucleotide excision repair proteinprovided by HGNC
Gene Summary: The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05039 | RAD23A Knockout cell line (HeLa) | Human | RAD23A | 1:3~1:6 | Negative | Online Inquiry |
KO05040 | RAD23A Knockout cell line (HCT 116) | Human | RAD23A | 1:2~1:4 | Negative | Online Inquiry |
KO05041 | RAD23A Knockout cell line (HEK293) | Human | RAD23A | 1:3~1:6 | Negative | Online Inquiry |
KO05042 | RAD23A Knockout cell line (A549) | Human | RAD23A | 1:3~1:4 | Negative | Online Inquiry |
RAD23A Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the RAD23A gene, which is integral to various cellular processes including DNA repair, protein degradation, and genomic stability. By eliminating the expression of RAD23A, these cell lines serve as powerful tools for investigating the gene's functional role in pivotal cellular pathways, especially those involved in response to DNA damage and stress.
The primary mechanism of action in these knockout cell lines lies in their ability to provide insights into the consequences of RAD23A deficiency. Researchers can observe alterations in cell cycle progression, apoptosis induction, and protein homeostasis under various experimental conditions. The high specificity of these cell lines allows for the elucidation of pathways influenced by RAD23A, offering a unique platform for studying the underlying mechanisms of diseases, particularly cancers where DNA repair mechanisms are often disrupted.
The scientific importance of RAD23A Gene Knockout Cell Lines extends to drug development and therapeutic interventions. By understanding how RAD23A affects cellular responses to chemotherapeutic agents, researchers can better predict drug efficacy and resistance, ultimately advancing personalized medicine approaches. Furthermore, the use of these knockout models can lead to novel discoveries in the fields of neurodegenerative diseases and aging.
One of the compelling advantages of RAD23A Gene Knockout Cell Lines over conventional models is their ability to provide a clean genetic background, minimizing the confounding variables often present in knockout animal models. This specificity enhances reproducibility and reliability in experiments, making them a preferred choice for many researchers.
This product is an invaluable asset for researchers and clinicians aiming to unravel the complexities of cellular behavior in response to genetic modifications. By utilizing RAD23A Gene Knockout Cell Lines, users can contribute to significant advancements in molecular biology, cancer research, and pharmacology.
Our company prides itself on its extensive experience in developing high-quality biological products tailored to the needs of the research community. We are committed to supporting scientific innovation and discovery with precision-engineered tools like RAD23A Gene Knockout Cell Lines, providing the backbone for your next groundbreaking study.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.