Gene: RAB18
Official Full Name: RAB18, member RAS oncogene familyprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00646 | RAB18 gRNA1-gRNA2 KO plasmid | RAB18 | $850 | |||
GP00648 | RAB18 gRNA3-gRNA4 KO plasmid | RAB18 | $850 | |||
KO14753 | RAB18 Knockout cell line (HeLa) | Human | RAB18 | 1:3~1:6 | Negative | Online Inquiry |
KO14754 | RAB18 Knockout cell line (HCT 116) | Human | RAB18 | 1:2~1:4 | Negative | Online Inquiry |
KO14755 | RAB18 Knockout cell line (HEK293) | Human | RAB18 | 1:3~1:6 | Negative | Online Inquiry |
KO14756 | RAB18 Knockout cell line (A549) | Human | RAB18 | 1:3~1:4 | Negative | Online Inquiry |
RAB18 Gene Knockout Cell Lines are specifically engineered cellular models that provide researchers with the ability to investigate the role of the RAB18 gene, which is implicated in various cellular processes including autophagy, lipid metabolism, and membrane trafficking. These knockout cell lines are created through advanced CRISPR/Cas9 gene-editing techniques, ensuring that the gene's expression is wholly disrupted, allowing for the study of the resultant phenotypic changes and underlying biological mechanisms.
The primary mechanism of action in RAB18 Gene Knockout Cell Lines centers around the loss of RAB18 protein function, which elucidates its contribution to endosomal dynamics and lipid storage processes. By studying these knockout lines, scientists can better understand the physiological impacts of RAB18 disruption and its correlations with lipid-related disorders such as Wolfram syndrome and other metabolic syndromes. The flexibility of these cell lines allows for various applications, including high-throughput screening, drug discovery, and therapeutic target validation.
One of the standout advantages of our RAB18 Gene Knockout Cell Lines is their unparalleled specificity and reliability compared to alternative models that may not fully recapitulate the RAB18 knockout phenotype. Researchers often face challenges with traditional knockdown studies due to potential off-target effects; our knockout models offer a clean genetic background, providing more accurate and reproducible results.
Furthermore, these cell lines serve as invaluable tools for clinicians and biopharmaceutical companies aiming to explore new avenues in therapeutic interventions targeting metabolic diseases. Their ease of use in various experimental setups accelerates the pace of research, ultimately aiding in the translation of findings into clinical applications.
At [Your Company Name], we pride ourselves on our expertise in developing cutting-edge biological products that empower researchers to advance their studies effectively. Our commitment to quality and innovation ensures that our RAB18 Gene Knockout Cell Lines are a crucial addition to any laboratory focused on metabolic research.
Please note that all services are for research use only. Not intended for any clinical use.
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