Gene: PXN
Official Full Name: paxillinprovided by HGNC
Gene Summary: This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08471 | PXN Knockout cell line (HeLa) | Human | PXN | 1:3~1:6 | Negative | Online Inquiry |
KO08472 | PXN Knockout cell line (HCT 116) | Human | PXN | 1:2~1:4 | Negative | Online Inquiry |
KO08473 | PXN Knockout cell line (HEK293) | Human | PXN | 1:3~1:6 | Negative | Online Inquiry |
KO08474 | PXN Knockout cell line (A549) | Human | PXN | 1:3~1:4 | Negative | Online Inquiry |
PXN Gene Knockout Cell Lines are specifically engineered cellular models in which the paxillin (PXN) gene has been effectively disrupted, allowing researchers to study the role of this critical cytoskeletal protein in various biological processes. Paxillin acts as an adapter protein, playing a pivotal role in cell adhesion, migration, and signal transduction pathways. By utilizing these knockout cell lines, scientists can delve deeper into mechanisms such as cell motility, tumor progression, and the response to mechanical stress, thus providing valuable insights into cellular dynamics and disease states.
The PXN Gene Knockout Cell Lines serve as an essential tool for understanding the functional consequences of paxillin depletion. In these models, the absence of PXN provides a controlled environment to assess changes in cellular morphology, adhesion properties, and intracellular signaling pathways. This functionality enables the exploration of new therapeutic targets, particularly in cancer research where cell migration and invasion are critical factors.
The significance of these knockout cell lines is accentuated in both research and clinical settings. They can be utilized to investigate the molecular mechanisms underlying various pathologies, including metastasis and cardiovascular diseases. Compared to other cell lines, the PXN knockout variant offers a unique opportunity to elucidate the specific involvement of paxillin in these processes, thereby advancing the field of cell biology.
Researchers and clinicians will find considerable value in the PXN Gene Knockout Cell Lines due to their specificity and reliability, enabling reproducible results for experimental designs focused on mechanistic studies. This product mitigates the ambiguous results that can arise from using wild-type cell lines, where the presence of functional PXN may confound experimental outcomes.
Our company prides itself on providing high-quality biological products that empower researchers and clinicians to gain unprecedented insights into cellular mechanisms. With our expertise in genomic engineering, we ensure that our PXN Gene Knockout Cell Lines are rigorously validated to meet the demanding standards of modern biological research, making them an indispensable asset for any laboratory focused on cell biology and related fields.
Please note that all services are for research use only. Not intended for any clinical use.
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