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PNMA1 Knockout Cell Lines

Gene: PNMA1

Official Full Name: PNMA family member 1provided by HGNC

Gene Summary: This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors. [provided by RefSeq, Feb 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33414 PNMA1 Knockout cell line (HeLa) Human PNMA1 1:3~1:6 Negative Online Inquiry
KO33415 PNMA1 Knockout cell line (HCT 116) Human PNMA1 1:2~1:4 Negative Online Inquiry
KO33416 PNMA1 Knockout cell line (HEK293) Human PNMA1 1:3~1:6 Negative Online Inquiry
KO33417 PNMA1 Knockout cell line (A549) Human PNMA1 1:3~1:4 Negative Online Inquiry

Background

PNMA1 Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically designed to eliminate the expression of the PNMA1 gene. This product serves as a vital tool for researchers aiming to investigate the functional role of PNMA1 in various biological processes and its implications in diseases, particularly neurological disorders. By strategically disrupting this gene, the cell lines provide a unique opportunity to study the downstream effects of PNMA1 disruption on cellular behavior and pathology.

The key function of these knockout cell lines is to facilitate loss-of-function studies, enabling researchers to elucidate the pathways affected by the absence of PNMA1. This involves examining various cellular mechanisms, including but not limited to cellular proliferation, apoptosis, and signal transduction. Through the utilization of these cell lines, scientists can gain insights into the potential tumor suppressor role of PNMA1 and its involvement in neurodegenerative conditions.

In terms of scientific importance, PNMA1 Gene Knockout Cell Lines are invaluable in both basic and translational research settings. Researchers can leverage these models to explore therapeutic strategies, assess drug responses, and validate potential biomarkers associated with diseases linked to PNMA1. Compared to non-targeted approaches, these knockout cell lines offer greater specificity and reproducibility, which enhances the reliability of the experimental results.

The distinct advantages of using PNMA1 Gene Knockout Cell Lines include their ease of use and adaptability for high-throughput screening applications. Unlike traditional knockdown methods, the complete knockout of PNMA1 ensures a more profound and permanent alteration in the cellular environment, allowing for clearer interpretation of experimental outcomes.

For researchers and clinicians seeking robust models for studying PNMA1, these cell lines are of immense value, offering critical insights that can spur novel therapeutic approaches. Furthermore, our company prides itself on delivering high-quality research tools backed by extensive expertise in genetic engineering and cell biology, ensuring that our products meet the rigorous demands of modern scientific inquiry. With a commitment to innovation and excellence, we provide resources that empower scientists to make impactful discoveries in their fields.

Please note that all services are for research use only. Not intended for any clinical use.

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