Gene: PLAG1
Official Full Name: PLAG1 zinc fingerprovided by HGNC
Gene Summary: Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36036 | PLAG1 Knockout cell line (HeLa) | Human | PLAG1 | 1:3~1:6 | Negative | Online Inquiry |
KO36037 | PLAG1 Knockout cell line (HEK293) | Human | PLAG1 | 1:3~1:6 | Negative | Online Inquiry |
PLAG1 Gene Knockout Cell Lines represent a versatile biotechnological tool designed for in-depth investigations into the role of the PLAG1 gene in various biological processes and diseases. PLAG1, known to be involved in growth regulation and oncogenesis, has significant implications in research related to cancer, developmental biology, and stem cell differentiation. The knockout cell lines are generated through advanced gene editing techniques, such as CRISPR-Cas9, ensuring precise excision of the PLAG1 gene. This enables researchers to create a controlled environment for studying the gene's functional contributions and its interaction with other genomic elements.
The key function of PLAG1 Gene Knockout Cell Lines lies in their ability to provide a platform for functional assays, drug screening, and mechanistic studies. By observing the phenotypic changes that occur in the absence of PLAG1, scientists can unravel its role in cellular processes, such as proliferation, apoptosis, and differentiation. These insights can pave the way for novel therapeutic strategies targeting PLAG1-related pathways, particularly in tumorigenesis.
Scientifically, the development of PLAG1 knockout models is pivotal for advancing our understanding of cancer biology and potential therapeutic interventions. Their application spans academic research, pharmaceutical development, and regenerative medicine, making them indispensable for researchers and clinicians aiming to address complex questions in health and disease.
A significant advantage of our PLAG1 Gene Knockout Cell Lines is their reliability and replicability, achieved through stringent quality control and validation protocols. Unlike alternative methods that may result in off-target effects or incomplete knockout, our cell lines provide a high-fidelity approach, ensuring that aberrations observed are solely attributable to the absence of PLAG1. Additionally, our user-friendly protocols facilitate seamless integration into existing research workflows, reducing time and resource expenditures.
For researchers and clinicians, the ability to work with precise knockout models accelerates the discovery of innovative treatments and lays the groundwork for future research avenues. Our extensive expertise in cell line development and commitment to supporting the scientific community means that we are not just providing a product, but are partners in advancing biomedicine. Experience the transformative potential of PLAG1 Gene Knockout Cell Lines, where cutting-edge science meets practical application.
Please note that all services are for research use only. Not intended for any clinical use.
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