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PEX10 Knockout Cell Lines

Gene: PEX10

Official Full Name: peroxisomal biogenesis factor 10provided by HGNC

Gene Summary: This gene encodes a protein involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane. Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger syndrome. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36129 PEX10 Knockout cell line (HeLa) Human PEX10 1:3~1:6 Negative Online Inquiry
KO36130 PEX10 Knockout cell line (HCT 116) Human PEX10 1:2~1:4 Negative Online Inquiry
KO36131 PEX10 Knockout cell line (HEK293) Human PEX10 1:3~1:6 Negative Online Inquiry
KO36132 PEX10 Knockout cell line (A549) Human PEX10 1:3~1:4 Negative Online Inquiry

Background

PEX10 Gene Knockout Cell Lines are specialized cellular models created through the targeted disruption of the PEX10 gene, which encodes a protein critical for peroxisome biogenesis and metabolic regulation in eukaryotic cells. These knockout cell lines serve as invaluable tools for studying the role of PEX10 in various cellular processes, including lipid metabolism, reactive oxygen species detoxification, and cellular signaling pathways.

The mechanism of action behind the PEX10 Gene Knockout involves the use of advanced CRISPR/Cas9 technology to induce specific mutations within the gene, resulting in the loss of function of the PEX10 protein. Consequently, researchers can elucidate the impact of PEX10 deficiency on cellular physiology, providing insights into the pathophysiology of peroxisomal disorders and other metabolic syndromes.

The scientific importance of PEX10 Gene Knockout Cell Lines cannot be overstated, as they are crucial in elucidating the functions of peroxisomes and have significant implications for drug discovery, gene therapy, and cellular biology research. By enabling precise studies of gene function, these models empower researchers to investigate disease mechanisms in conditions such as Zellweger syndrome and other inherited metabolic disorders linked to peroxisomal dysfunction.

When compared to alternative models, PEX10 Gene Knockout Cell Lines exhibit unique advantages, including a highly specific gene disruption, consistency in experimental outcomes, and the ability to be customized for various applications. These cell lines offer greater fidelity in mimicking native biological responses, which enhances the reliability and relevance of experimental findings.

For researchers and clinicians focused on metabolic diseases, oxidative stress responses, or cellular signaling, PEX10 Gene Knockout Cell Lines represent an essential resource. Their ability to provide clear insights into complex biological systems makes them indispensable for advancing the frontiers of scientific knowledge and therapeutic development.

Our company specializes in delivering high-quality biological products, including an extensive range of gene knockout models. Our commitment to precision and excellence ensures that researchers have access to the best tools for their investigations, making invaluable contributions to the fields of genetics, molecular biology, and translational medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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