Gene: PCMT1
Official Full Name: protein-L-isoaspartate (D-aspartate) O-methyltransferaseprovided by HGNC
Gene Summary: This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36190 | PCMT1 Knockout cell line (HeLa) | Human | PCMT1 | 1:3~1:6 | Negative | Online Inquiry |
KO36191 | PCMT1 Knockout cell line (HCT 116) | Human | PCMT1 | 1:2~1:4 | Negative | Online Inquiry |
KO36192 | PCMT1 Knockout cell line (HEK293) | Human | PCMT1 | 1:3~1:6 | Negative | Online Inquiry |
KO36193 | PCMT1 Knockout cell line (A549) | Human | PCMT1 | 1:3~1:4 | Negative | Online Inquiry |
PCMT1 Gene Knockout Cell Lines are specifically engineered cellular models that lack the expression of the PCMT1 gene, which encodes the protein would otherwise play a crucial role in cellular processes such as protein methylation and post-translational modifications. By utilizing CRISPR-Cas9 technology or other gene-editing techniques, these knockout cell lines provide researchers with a powerful tool to investigate the functional implications of the PCMT1 gene, thus facilitating a deeper understanding of its role in various biological pathways and disease states.
The key mechanism of function lies in the absence of the PCMT1 protein, which is implicated in the regulation of protein stability and signal transduction pathways. By studying these knockout cells, researchers can explore the consequences of disrupted protein methylation, which may contribute to alterations in cellular homeostasis, proliferation, and differentiation. This allows for an assessment of how the loss of PCMT1 influences mechanisms associated with pathologies such as cancer, neurodegenerative diseases, and metabolic disorders.
In scientific and clinical research settings, PCMT1 Gene Knockout Cell Lines have significant applications. They serve as an invaluable resource for drug discovery, biomarker identification, and toxicological studies. Furthermore, they can aid in deciphering the complex interactions that govern cellular responses in disease models, making them essential for developing targeted therapeutic strategies.
One of the distinct advantages of our PCMT1 Gene Knockout Cell Lines is the meticulous validation process each line undergoes to ensure genuine and reproducible knockout efficiency, surpassing alternatives that may offer less reliable genetic modifications. Furthermore, our cell lines are derived from multiple backgrounds, allowing researchers to select the most suitable model for their specific applications, something not commonly available with competing products.
Our PCMT1 Gene Knockout Cell Lines represent a critical resource for researchers and clinicians aiming to unlock new insights into disease mechanisms, ultimately contributing to improved therapeutic interventions. With our extensive expertise in genetic engineering and cell line development, we take pride in offering high-quality biological products that empower the scientific community in their quest for discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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