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PARD6B Knockout Cell Lines

Gene: PARD6B

Official Full Name: par-6 family cell polarity regulator betaprovided by HGNC

Gene Summary: This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08657 PARD6B Knockout cell line (HeLa) Human PARD6B 1:3~1:6 Negative Online Inquiry
KO08658 PARD6B Knockout cell line (HCT 116) Human PARD6B 1:2~1:4 Negative Online Inquiry
KO08659 PARD6B Knockout cell line (HEK293) Human PARD6B 1:3~1:6 Negative Online Inquiry
KO08660 PARD6B Knockout cell line (A549) Human PARD6B 1:3~1:4 Negative Online Inquiry

Background

PARD6B Gene Knockout Cell Lines are genetically modified cell lines where the PARD6B gene has been specifically disrupted, allowing researchers to study the functional consequences of its absence in a controlled environment. The PARD6B gene is integral to various cellular processes, including cell polarity, migration, and signaling pathways. By utilizing these knockout cell lines, scientists can elucidate the biological roles of PARD6B and its implications in cellular behavior and disease states, especially in cancer and developmental biology.

The mechanism underlying these knockout cell lines involves CRISPR-Cas9 technology, which enables precise editing of the genome. By targeting the specific loci of the PARD6B gene, researchers can create effective gene disruptions. This method allows for the observation of phenotypic changes, assessment of alternative pathways, and insights into how the loss of PARD6B affects cellular processes such as adhesion and growth factor response.

Scientifically, PARD6B Gene Knockout Cell Lines are invaluable tools for exploring signaling networks and cell dynamics, making them crucial for both basic research and translational studies. Their applications extend into drug development and therapeutic strategies, where understanding gene function and interaction pathways can lead to innovative approaches in treatment modalities.

Compared to alternative products such as knockdown systems or non-specific gene editing tools, our PARD6B Gene Knockout Cell Lines offer specificity and the capacity for functional assays that accurately mimic physiological responses. Researchers can depend on these lines to produce reproducible and significant results, leading to more profound insights and faster progression in their studies.

Our commitment to providing top-tier biological products is backed by years of experience and expertise in genetic engineering and molecular biology. With a focus on quality and reliability, we ensure that our PARD6B Gene Knockout Cell Lines deliver exceptional value to researchers and clinicians, facilitating advancements in scientific knowledge and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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