Gene: P4HB
Official Full Name: prolyl 4-hydroxylase subunit betaprovided by HGNC
Gene Summary: This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01953 | P4HB Knockout cell line (HeLa) | Human | P4HB | 1:3~1:6 | Negative | Online Inquiry |
KO01954 | P4HB Knockout cell line (HCT 116) | Human | P4HB | 1:2~1:4 | Negative | Online Inquiry |
KO01955 | P4HB Knockout cell line (HEK293) | Human | P4HB | 1:3~1:6 | Negative | Online Inquiry |
KO01956 | P4HB Knockout cell line (A549) | Human | P4HB | 1:3~1:4 | Negative | Online Inquiry |
P4HB Gene Knockout Cell Lines are specialized cellular models engineered to disrupt the expression of the P4HB gene, which encodes for protein disulfide isomerase. This product serves as an invaluable tool for researchers investigating the functional roles of P4HB in various biological processes, including intracellular protein folding, oxidative stress responses, and cell signaling pathways. By employing CRISPR/Cas9 technology, these cell lines allow for precise genomic editing, enabling the study of gene function and the identification of potential therapeutic targets.
The key function of P4HB Gene Knockout Cell Lines lies in their ability to facilitate investigations into the implications of P4HB in cellular physiology and pathology. The knockout of the P4HB gene creates a system where researchers can discern the consequences of its absence on protein maturation and cellular stress responses. This model is particularly relevant in studies related to cancer biology, where P4HB’s role in promoting tumor cell survival and proliferation may be elucidated.
From a scientific perspective, P4HB Gene Knockout Cell Lines are essential for advancing our understanding of disease mechanisms and developing novel therapeutic strategies. Their application extends to drug screening and biomarker discovery, yielding insights that could lead to innovative treatments.
What differentiates P4HB Gene Knockout Cell Lines from other genetic models is the high specificity and efficiency of the CRISPR/Cas9 knockout approach. Traditional methods, such as siRNA knockdown or chemical inhibitors, may yield transient results or off-target effects, whereas these knockout cell lines provide stable and reproducible data for long-term investigations. Moreover, these cell lines can be adapted for high-throughput screening, making them ideal for pharmaceutical research and development.
For researchers and clinicians seeking to deepen their understanding of the P4HB gene’s role in cellular mechanisms, the P4HB Gene Knockout Cell Lines present a versatile and robust solution. Our company is committed to providing cutting-edge biological products, backed by years of expertise in genetic engineering and cell biology, ensuring you have access to the highest quality models for your research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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