Home / Otud5 Knockout Cell Lines

Otud5 Knockout Cell Lines

Gene: OTUD5

Official Full Name: OTU deubiquitinase 5provided by HGNC

Gene Summary: This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00446 Otud5 gRNA3-gRNA4 KO plasmid Otud5 $850
GP00456 Otud5 gRNA5-gRNA6 KO plasmid Otud5 $850

Background

OTUD5 Gene Knockout Cell Lines are genetically modified cell lines in which the OTUD5 gene has been specifically inactivated through targeted gene editing techniques, such as CRISPR-Cas9. The OTUD5 gene encodes a deubiquitinating enzyme that plays a crucial role in regulating various cellular processes, including protein degradation, signal transduction, and the cellular response to stress. By creating knockout models, researchers can effectively study the exact contributions of the OTUD5 protein to these biological pathways and its implications in diseases, including cancers and neurodegenerative disorders.

The primary function of these knockout cell lines is to provide a controlled environment for researchers to observe the physiological and molecular changes that result from the absence of the OTUD5 protein. This enables investigations into the mechanistic roles of OTUD5 in cellular signaling pathways and responses to stressors, which could reveal potential therapeutic targets for drug development.

Scientifically, the OTUD5 Gene Knockout Cell Lines hold significant importance in both research and clinical applications. They facilitate the study of gene function, elucidate disease mechanisms, and contribute to the development of potential interventions. This product is especially valuable in fields such as oncology, where understanding the gene's role can lead to innovative treatments.

When compared to alternative methods, such as RNA interference (RNAi), the OTUD5 knockout approach offers a more permanent and precise means of gene inactivation, enabling researchers to bypass the transient effects of RNAi and achieve consistent results over time. Additionally, the specificity of gene knockout minimizes off-target effects, enhancing the reliability of experimental outcomes.

The availability of OTUD5 Gene Knockout Cell Lines is particularly valuable for researchers, clinicians, and drug developers who are seeking to advance knowledge in gene function and develop new therapeutic strategies. With our company’s commitment to scientific excellence and innovation, we provide high-quality biological products that empower researchers to unlock the complexities of the genome and propel forward the field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.