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NSUN5 Knockout Cell Lines

Gene: NSUN5

Official Full Name: NOP2/Sun RNA methyltransferase 5provided by HGNC

Gene Summary: This gene encodes a member of an evolutionarily conserved family of proteins that may function as methyltransferases. This gene is located in a larger region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder. There are two pseudogenes for this gene located in the same region of chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15613 NSUN5 Knockout cell line (HeLa) Human NSUN5 1:3~1:6 Negative Online Inquiry
KO15614 NSUN5 Knockout cell line (HCT 116) Human NSUN5 1:2~1:4 Negative Online Inquiry
KO15615 NSUN5 Knockout cell line (HEK293) Human NSUN5 1:3~1:6 Negative Online Inquiry
KO15616 NSUN5 Knockout cell line (A549) Human NSUN5 1:3~1:4 Negative Online Inquiry

Background

NSUN5 Gene Knockout Cell Lines are genetically engineered cell lines designed to specifically disrupt the function of the NSUN5 gene, which is implicated in cellular processes such as RNA methylation and gene expression regulation. Through advanced CRISPR/Cas9 technology, these knockout lines provide a reliable model for studying the functional consequences of NSUN5 loss on cell behavior, signaling pathways, and overall cellular physiology.

The key function of the NSUN5 gene involves the addition of a methyl group to RNA molecules, crucial for RNA stability, processing, and translation. By creating knockout cell lines, researchers can meticulously investigate how the absence of NSUN5 alters gene expression, cellular response to stressors, and overall cellular health. This mechanistic insight is invaluable for understanding various pathologies, including cancer and neurodegenerative disorders, where aberrant RNA modification is often observed.

The scientific importance of these cell lines extends to both research and clinical applications. They serve as a powerful tool for investigating the role of NSUN5 in disease models, aiding in the development of therapeutic strategies that target RNA methylation processes. Additionally, these cell lines can be utilized in drug screening assays to identify potential small molecules that modulate NSUN5 activity, paving the way for novel treatment options.

What sets NSUN5 Gene Knockout Cell Lines apart from traditional cell models is their precision and specificity. Existing alternatives may not offer the level of control provided by knockout technologies, leading to more reliable and reproducible results. Furthermore, these cell lines enable researchers to focus directly on the biological consequences of NSUN5 depletion without the confounding effects of other genes.

For researchers and clinicians, the NSUN5 Gene Knockout Cell Lines are an invaluable asset, facilitating groundbreaking insights into gene function and disease mechanisms. Our commitment to excellence in the development of high-quality biological products is underscored by our team’s expertise in genetic engineering, ensuring that our offerings consistently meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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