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NMB Knockout Cell Lines

Gene: NMB

Official Full Name: neuromedin Bprovided by HGNC

Gene Summary: This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06955 NMB Knockout cell line (HeLa) Human NMB 1:3~1:6 Negative Online Inquiry
KO06956 NMB Knockout cell line (HCT 116) Human NMB 1:2~1:4 Negative Online Inquiry
KO06957 NMB Knockout cell line (HEK293) Human NMB 1:3~1:6 Negative Online Inquiry
KO06958 NMB Knockout cell line (A549) Human NMB 1:3~1:4 Negative Online Inquiry

Background

NMB Gene Knockout Cell Lines are genetically engineered cell lines that have had the neuropeptide B (NMB) gene selectively disrupted using advanced CRISPR-Cas9 technology. This innovative approach allows researchers to study the functional roles of NMB and its receptor interactions in various biological processes, including neuroendocrine functions and stress response mechanisms. By effectively silencing the NMB gene, these cell lines serve as a crucial tool for elucidating the underlying pathways involved in cellular communication and signaling.

The key function of the NMB Gene Knockout Cell Lines lies in their ability to provide insights into the physiological and pathological roles of NMB. NMB is known to influence a variety of functions, including appetite regulation, pain perception, and modulation of stress responses. Understanding these mechanisms is essential for research into neuropsychiatric disorders and metabolic conditions. The knockout configuration enables targeted investigations into how the absence of NMB alters cellular behavior, thus paving the road for developing targeted therapeutic strategies.

From a scientific perspective, these cell lines are invaluable for drug discovery, allowing for high-throughput screening of potential compounds aimed at modulating NMB pathways. Additionally, they serve as a foundation for studies examining the synergistic effects of NMB with other neuropeptides and neurotransmitters, thereby enhancing our understanding of complex biological interactions.

Compared to traditional methods of gene disruption, NMB Gene Knockout Cell Lines offer superior precision and efficiency due to the CRISPR-Cas9 system. This method minimizes off-target effects and accelerates the timeline for obtaining viable knockout cell lines. The robust genetic stability of these models further ensures reproducibility in experimental setups, an essential factor for obtaining reliable results.

For researchers and clinicians alike, the value of NMB Gene Knockout Cell Lines lies in their capacity to advance knowledge in neurobiology and therapeutic developments. By utilizing these sophisticated tools, users can deepen their exploration of neuropeptide signaling and its implications in health and disease.

As a leader in genetic engineering solutions, our company is committed to providing high-quality biological products that empower researchers to make groundbreaking discoveries. With our experience and dedication to precision, we continue to support advancements in biomedical science.

Please note that all services are for research use only. Not intended for any clinical use.

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