Gene: NECTIN2
Official Full Name: nectin cell adhesion molecule 2provided by HGNC
Gene Summary: This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35757 | NECTIN2 Knockout cell line (HeLa) | Human | NECTIN2 | 1:3~1:6 | Negative | Online Inquiry |
KO35758 | NECTIN2 Knockout cell line (HCT 116) | Human | NECTIN2 | 1:2~1:4 | Negative | Online Inquiry |
KO35759 | NECTIN2 Knockout cell line (HEK293) | Human | NECTIN2 | 1:3~1:6 | Negative | Online Inquiry |
KO35760 | NECTIN2 Knockout cell line (A549) | Human | NECTIN2 | 1:3~1:4 | Negative | Online Inquiry |
NECTIN2 Gene Knockout Cell Lines are advanced biological tools specifically engineered to facilitate targeted studies of the NECTIN2 gene, which plays a critical role in cellular adhesion and immune responses. Utilizing CRISPR/Cas9 gene-editing technology, these cell lines are created to possess a complete knockout of the NECTIN2 gene, allowing researchers to investigate the gene's biological functions and its implications in various physiological and pathological processes.
The primary mechanism by which NECTIN2 Gene Knockout Cell Lines operate involves the disruption of the NECTIN2 gene, leading to the absence of its associated protein. This enables researchers to study the resulting phenotypic changes in cell behavior, such as alterations in cell adhesion, migration, and communication. Understanding these changes has significant implications for cancer research, immunology, and developmental biology, making these cell lines invaluable tools in both basic and applied sciences.
Scientifically, understanding the role of NECTIN2 is increasingly relevant in clinical settings, particularly concerning its involvement in tumorigenesis and immunotherapeutic responses. The NECTIN2 gene has been associated with various cancers, and its knockout models can help in elucidating potential targets for therapeutic intervention.
Compared to alternative gene-editing tools, our NECTIN2 Gene Knockout Cell Lines offer enhanced precision and reliability, ensuring that researchers can achieve reproducible results with minimal off-target effects. These lines are compatible with a wide range of assays, making them ideal for diverse experimental setups.
Researchers and clinicians can significantly benefit from the implementation of these knockout cell lines in their studies, as they directly contribute to a deeper understanding of cell biology and disease mechanisms. By providing a robust and specific model for investigation, these cell lines pave the way for innovations in treatment strategies and novel research findings.
Our company specializes in creating high-quality gene knockout models, leveraging cutting-edge technologies to ensure that our products meet the highest standards of scientific rigor and usability. With a commitment to advancing research, we strive to support the scientific community with tools that facilitate meaningful discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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