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NDUFAF5 Knockout Cell Lines

Gene: NDUFAF5

Official Full Name: NADH:ubiquinone oxidoreductase complex assembly factor 5provided by HGNC

Gene Summary: The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes a mitochondrial protein that is associated with the matrix face of the mitochondrial inner membrane and is required for complex I assembly. A mutation in this gene results in mitochondrial complex I deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15794 NDUFAF5 Knockout cell line (HeLa) Human NDUFAF5 1:3~1:6 Negative Online Inquiry
KO15795 NDUFAF5 Knockout cell line (HCT 116) Human NDUFAF5 1:2~1:4 Negative Online Inquiry
KO15796 NDUFAF5 Knockout cell line (HEK293) Human NDUFAF5 1:3~1:6 Negative Online Inquiry
KO15797 NDUFAF5 Knockout cell line (A549) Human NDUFAF5 1:3~1:4 Negative Online Inquiry

Background

NDUFAF5 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the roles and mechanisms of the NDUFAF5 gene, which encodes a fundamental component of mitochondrial respiratory chain complex I. This product features cell lines in which the NDUFAF5 gene has been precisely knocked out using advanced CRISPR-Cas9 technology, creating a powerful tool for investigating energy metabolism, mitochondrial dysfunction, and related diseases.

These knockout cell lines function as valuable experimental systems to examine the consequential alterations in cellular metabolism and the resultant physiological effects due to the absence of NDUFAF5. This gene is known to play a vital role in facilitating the assembly and stability of the mitochondrial respiratory complex, thus affecting ATP production and overall cellular energy homeostasis. By using these cell lines, researchers can gain insights into disorders linked to mitochondrial inefficiencies, such as neurodegenerative diseases, metabolic syndromes, and certain types of cancer.

The scientific importance of NDUFAF5 Gene Knockout Cell Lines cannot be overstated, as they offer an unparalleled opportunity for both basic and applied research. In clinical settings, these models can aid in the drug discovery process and in assessing the therapeutic potential of mitochondrial-targeting compounds. Additionally, they enable researchers to delineate the pathways affected by NDUFAF5 deficiency, enhancing our understanding of mitochondrial disease mechanisms.

Compared to traditional models, the unique selling points of our NDUFAF5 Gene Knockout Cell Lines include their specificity and the precision of gene editing. While conventional cell lines may present background expression of the NDUFAF5 gene, our knockout model ensures a complete lack of expression, providing more accurate and reliable results. Furthermore, these cell lines can be easily cultured and adapted for high-throughput screening, facilitating a more efficient research process.

For researchers and clinicians seeking to unravel the complexities of mitochondrial biology, NDUFAF5 Gene Knockout Cell Lines represent an invaluable resource. Developing a deeper understanding of mitochondrial function not only advances fundamental science but also holds significant promise in translational research aimed at developing novel therapeutics.

With extensive experience in producing high-quality biological products, our company is committed to providing tools that empower research excellence. Our expertise ensures that our NDUFAF5 Gene Knockout Cell Lines meet the rigorous standards required for impactful scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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