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NCS1 Knockout Cell Lines

Gene: NCS1

Official Full Name: neuronal calcium sensor 1provided by HGNC

Gene Summary: This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29321 NCS1 Knockout cell line (HeLa) Human NCS1 1:3~1:6 Negative Online Inquiry
KO29322 NCS1 Knockout cell line (HCT 116) Human NCS1 1:2~1:4 Negative Online Inquiry
KO29323 NCS1 Knockout cell line (HEK293) Human NCS1 1:3~1:6 Negative Online Inquiry
KO29324 NCS1 Knockout cell line (A549) Human NCS1 1:3~1:4 Negative Online Inquiry

Background

NCS1 Gene Knockout Cell Lines are sophisticated biological research tools designed to facilitate the study of neuronal signaling mechanisms through the knockout of the neuronal calcium sensor 1 (NCS1) gene. These engineered cell lines provide a unique platform for researchers to investigate the functional role of NCS1 in calcium-dependent cellular processes, particularly in the context of synaptic transmission, neurodegenerative diseases, and cellular signaling pathways.

The primary function of these cell lines is to provide a model for examining the physiological and pathological implications of NCS1 absence. By utilizing CRISPR/Cas9 genome editing technology, the knockout of the NCS1 gene leads to the disruption of its normal physiological function. This provides insights into the molecular mechanisms whereby NCS1 influences calcium homeostasis and subsequent cellular responses, allowing for a deeper understanding of its role in various neurological disorders.

In both research and clinical settings, NCS1 Gene Knockout Cell Lines are invaluable for drug discovery and the identification of novel therapeutic targets. The ability to model conditions such as schizophrenia, bipolar disorder, and other neuropsychiatric disorders has made these cell lines essential in the development of pharmacological interventions and understanding disease etiology.

One of the distinctive advantages of using NCS1 Gene Knockout Cell Lines is their specificity and reliability compared to traditional methods of gene silencing, such as siRNA or shRNA approaches, which can lead to off-target effects. Furthermore, their consistent performance in vitro allows for reproducible experimental outcomes, enhancing the reliability of research findings.

Our commitment to scientific excellence and innovation ensures that NCS1 Gene Knockout Cell Lines are produced under stringent quality controls, enabling researchers and clinicians to undertake pioneering studies with confidence. With a comprehensive understanding of gene function and its implications in health and disease, our company stands at the forefront of providing essential tools for advancing biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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