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NBPF1 Knockout Cell Lines

Gene: NBPF1

Official Full Name: NBPF member 1provided by HGNC

Gene Summary: This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, Apr 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15847 NBPF1 Knockout cell line (HeLa) Human NBPF1 1:3~1:6 Negative Online Inquiry
KO15848 NBPF1 Knockout cell line (HCT 116) Human NBPF1 1:2~1:4 Negative Online Inquiry
KO15849 NBPF1 Knockout cell line (HEK293) Human NBPF1 1:3~1:6 Negative Online Inquiry
KO15850 NBPF1 Knockout cell line (A549) Human NBPF1 1:3~1:4 Negative Online Inquiry

Background

NBPF1 Gene Knockout Cell Lines are specialized cellular models wherein the NBPF1 gene has been deliberately disrupted or "knocked out" to assess its function and implications within various biological contexts. This genetic manipulation serves as a critical tool in understanding gene function, studying disease mechanisms, and enabling therapeutic development. The key mechanism behind the functionality of these cell lines lies in the use of CRISPR-Cas9 technology, which allows for precise genomic editing, resulting in the elimination of the NBPF1 gene, thereby facilitating thorough investigation of its biological roles.

The scientific importance of NBPF1 Gene Knockout Cell Lines extends beyond basic research; they have significant applications in studying neurodevelopmental disorders, cancers, and other pathophysiological conditions associated with the NBPF1 gene. Researchers can utilize these cell lines to explore cellular pathways, gene interactions, and biomolecular processes influenced by NBPF1, thus addressing critical gaps in current biomedical knowledge and offering insights into potential therapeutic interventions.

One of the primary advantages of using NBPF1 Gene Knockout Cell Lines is their specificity and consistency, which provide high reproducibility in experimental results compared to traditional methods such as RNA interference (RNAi). Furthermore, these models eliminate the off-target effects often associated with other genome-editing techniques, allowing researchers to confidently attribute observed phenotypes to the targeted knockout. This precision makes our cell lines uniquely valuable to researchers and clinicians striving for reliable data.

By integrating rigorous quality control processes and offering detailed characterization insights, our NBPF1 Gene Knockout Cell Lines stand out within the competitive landscape of genetically modified models. These cell lines are invaluable resources that enhance the ability to unearth novel biological mechanisms, thereby driving innovation and discovery in research.

Our company's commitment to advancing the field of genetic research is underscored by our expertise in cellular engineering and the provision of high-quality biological products. We are dedicated to equipping researchers with the tools needed to push the boundaries of science, ultimately contributing to improved health outcomes and therapeutic solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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