Gene: NADK2
Official Full Name: NAD kinase 2, mitochondrialprovided by HGNC
Gene Summary: This gene encodes a mitochondrial kinase that catalyzes the phosphorylation of NAD to yield NADP. Mutations in this gene result in 2,4-dienoyl-CoA reductase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00986 | NADK2 Knockout cell line (A549) | Human | NADK2 | 1:3~1:4 | Negative | Online Inquiry |
KO26477 | NADK2 Knockout cell line (HeLa) | Human | NADK2 | 1:3~1:6 | Negative | Online Inquiry |
KO26478 | NADK2 Knockout cell line (HCT 116) | Human | NADK2 | 1:2~1:4 | Negative | Online Inquiry |
KO26479 | NADK2 Knockout cell line (HEK293) | Human | NADK2 | 1:3~1:6 | Negative | Online Inquiry |
NADK2 Gene Knockout Cell Lines are expertly engineered cellular models that have been developed to understand the biological functions associated with the NADK2 gene, which encodes for NAD kinase 2, an essential enzyme involved in the synthesis of NADPH from NADP+. These cell lines are invaluable for researchers aiming to investigate the metabolic pathways that NADPH influences, including fatty acid synthesis, cellular proliferation, and oxidative stress responses.
The primary function of NADK2 is to regulate the cellular levels of NADPH, a crucial cofactor in anabolic reactions and antioxidant defense mechanisms. By selectively knocking out the NADK2 gene, these cell lines allow for detailed analysis of the compensatory mechanisms and adaptive responses that cells employ in the absence of this enzyme, providing insights into the essential pathways that drive various diseases, including cancer and metabolic disorders.
Scientifically, NADK2 Gene Knockout Cell Lines are significant for both basic research and clinical applications, facilitating studies on metabolic regulation, drug development, and therapeutic interventions. Researchers can leverage these models to test hypotheses related to nutrient metabolism, oxidative stress, and their roles in disease pathology, paving the way for novel treatments and interventions.
Compared to traditional cell lines, the NADK2 knockout models offer unique advantages by providing a precise genetic alteration to study the NADK2 gene's specific impact on cellular function. This targeted approach allows for cleaner interpretation of experimental results without the confounding variables often associated with chemical inhibitors or other less precise genetic manipulation techniques.
For researchers and clinicians alike, the value of NADK2 Gene Knockout Cell Lines lies in their ability to provide deeper insights into the mechanisms of pathophysiology, making them essential tools in the quest for innovative therapeutic strategies. Our company specializes in the production of high-quality, validated biological products tailored to meet the rigorous demands of contemporary research, ensuring that our clients have access to the very best tools to advance their scientific inquiries.
Please note that all services are for research use only. Not intended for any clinical use.
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