Gene: MYL2
Official Full Name: myosin light chain 2provided by HGNC
Gene Summary: This gene encodes a major sarcomeric protein in mammalian striated muscle. The encoded protein plays a role in embryonic heart muscle structure and function, while phosphorylation of the encoded protein is involved in cardiac myosin cycling kinetics, torsion and function in adults. Mutations in this gene are associated with hypertrophic cardiomyopathy 10 and infant-onset myopathy. [provided by RefSeq, May 2022]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08434 | MYL2 Knockout cell line (HCT 116) | Human | MYL2 | 1:2~1:4 | Negative | Online Inquiry |
MYL2 Gene Knockout Cell Lines are a specialized line of genetically engineered cells that have had the MYL2 gene specifically disrupted, offering researchers an invaluable tool for studying the functional role of this gene in cardiovascular biology and muscle physiology. The MYL2 gene encodes the regulatory light chain of myosin in cardiac muscle, and its knockout enables scientists to investigate the implications of MYL2 deficiency in contractile function, myocyte development, and heart disease progression.
Key functions of the MYL2 Gene Knockout Cell Lines stem from their ability to model pathophysiological conditions associated with altered myosin dynamics. By eliminating the MYL2 gene, researchers can observe changes in cell signaling pathways, muscle contraction mechanisms, and the cellular response to stress factors, creating a comprehensive platform to explore potential therapeutic targets for conditions such as hypertrophic cardiomyopathy or heart failure.
The scientific importance of these knockout cell lines extends beyond basic research; they are instrumental in preclinical drug development, allowing for the identification and validation of compounds that may enhance cardiac function or protect against myosin-related dysregulation. In clinical settings, understanding MYL2 interactions could inform personalized treatment strategies for patients with genetic predispositions to cardiac disorders.
Unlike traditional cell lines, the MYL2 Gene Knockout Cell Lines provide a unique advantage by mimicking disease states with high fidelity, offering precise insights that enhance experimental outcomes. Furthermore, these cell lines are custom-engineered using advanced CRISPR/Cas9 gene-editing technology, ensuring reliability and reproducibility in experimental setups.
For researchers and clinicians focused on cardiac biology and therapeutic interventions, the MYL2 Gene Knockout Cell Lines represent an essential asset that aligns with pioneering research efforts. Our company prides itself on delivering cutting-edge biological products, backed by expertise in genetic engineering and cell biology, to support scientific advancement and improve patient outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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