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MRPL3 Knockout Cell Lines

Gene: MRPL3

Official Full Name: mitochondrial ribosomal protein L3provided by HGNC

Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31059 MRPL3 Knockout cell line (HeLa) Human MRPL3 1:3~1:6 Negative Online Inquiry
KO31060 MRPL3 Knockout cell line (HCT 116) Human MRPL3 1:2~1:4 Negative Online Inquiry
KO31061 MRPL3 Knockout cell line (HEK293) Human MRPL3 1:3~1:6 Negative Online Inquiry

Background

MRPL3 Gene Knockout Cell Lines represent a groundbreaking tool in molecular biology, providing researchers with specialized cell lines in which the MRPL3 gene has been completely inactivated. The MRPL3 gene encodes a mitochondrial ribosomal protein essential for mitochondrial protein synthesis, making it critical for cellular energy production and metabolism. The knockout of this gene allows for the precise investigation of its role in mitochondrial function and the broader implications of mitochondrial dysfunction in various diseases, including cancer and neurodegenerative disorders.

These cell lines facilitate key research functions such as the assessment of metabolic pathways, evaluation of cellular stress responses, and investigation of apoptosis mechanisms. By eliminating the MRPL3 gene, researchers can observe alterations in mitochondrial biogenesis, respiratory chain activity, and overall cellular homeostasis, thereby unveiling potential therapeutic targets for mitochondrial-related diseases.

The scientific importance of MRPL3 Gene Knockout Cell Lines extends to various research and clinical applications, enabling studies that seek to understand the etiology of mitochondrial diseases and their impact on cellular physiology in health and disease. These models can be crucial for drug discovery, enabling the testing of new compounds that modulate mitochondrial function.

What sets these knockout cell lines apart from existing alternatives is their specificity and reliability. Developed using advanced CRISPR/Cas9 technology, our MRPL3 knockout cell lines offer enhanced precision, ensuring that the gene modification is both accurate and reproducible. This high level of precision allows researchers to draw more reliable conclusions while minimizing experimental variability.

Incorporating MRPL3 Gene Knockout Cell Lines into research protocols can accelerate discoveries in mitochondrial biology and its clinical implications, making them invaluable to researchers, clinicians, and pharmaceutical companies alike. These insights could lead to breakthroughs in targeted therapies and more effective treatments for mitochondrial dysfunctions.

At [Company Name], our dedication to advancing scientific research is exemplified through our high-quality biological products, developed by a team of expert scientists committed to innovation and excellence, ensuring that researchers have access to the tools necessary for meaningful discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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