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MPDU1 Knockout Cell Lines

Gene: MPDU1

Official Full Name: mannose-P-dolichol utilization defect 1provided by HGNC

Gene Summary: This gene encodes an endoplasmic reticulum membrane protein that is required for utilization of the mannose donor mannose-P-dolichol in the synthesis of lipid-linked oligosaccharides and glycosylphosphatidylinositols. Mutations in this gene result in congenital disorder of glycosylation type If. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33132 MPDU1 Knockout cell line (HeLa) Human MPDU1 1:3~1:6 Negative Online Inquiry
KO33133 MPDU1 Knockout cell line (HCT 116) Human MPDU1 1:2~1:4 Negative Online Inquiry
KO33134 MPDU1 Knockout cell line (HEK293) Human MPDU1 1:3~1:6 Negative Online Inquiry
KO33135 MPDU1 Knockout cell line (A549) Human MPDU1 1:3~1:4 Negative Online Inquiry

Background

MPDU1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the MPDU1 gene, which encodes a crucial protein involved in the glycosylation pathway. The knockout of this gene significantly impacts the formation of glycoproteins, providing an invaluable tool for researchers studying carbohydrate metabolism, protein folding, and cellular signaling pathways.

The primary function of these cell lines is to enable the investigation of MPDU1's role in glycosylation and its broader implications in cellular physiology. By eliminating MPDU1, scientists can observe the resultant metabolic alterations, leading to a deeper understanding of how glycosylation affects protein stability and function. MPDU1 knockout cell lines are particularly beneficial for studies on diseases that are associated with glycosylation defects, such as congenital disorders of glycosylation (CDGs) and various cancer types.

The scientific importance of using MPDU1 Gene Knockout Cell Lines extends to both basic and translational research contexts. In the laboratory, these cell lines facilitate the exploration of glycoprotein-related mechanisms and support drug development by offering a platform for screening compounds that modulate glycosylation processes. Clinically, insights gained from such studies can translate into therapeutic strategies targeting glycosylation-related diseases.

Compared to other knockout models, MPDU1 Gene Knockout Cell Lines provide unique advantages by offering a precise and focused approach to understanding glycosylation's role within the cell. Their ability to recreate specific metabolic scenarios allows researchers to yield more relevant and robust data, thereby minimizing assumptions based on non-targeted knockout strategies.

For researchers and clinicians, the value of MPDU1 Gene Knockout Cell Lines lies in their capacity to illuminate critical biological processes and foster innovations in therapeutic interventions. By utilizing these specialized cell lines, users can advance their understanding of intricate cellular mechanisms and contribute to groundbreaking research findings.

Our company is committed to providing high-quality biological products, backed by extensive expertise in genetic engineering and cell line development. We strive to support the scientific community by offering tools that empower researchers in their quest for deeper biological insights.

Please note that all services are for research use only. Not intended for any clinical use.

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