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MKS1 Knockout Cell Lines

Gene: MKS1

Official Full Name: MKS transition zone complex subunit 1provided by HGNC

Gene Summary: The protein encoded by this gene localizes to the basal body and is required for formation of the primary cilium in ciliated epithelial cells. Mutations in this gene result in Meckel syndrome type 1 and in Bardet-Biedl syndrome type 13. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36616 MKS1 Knockout cell line (HeLa) Human MKS1 1:3~1:6 Negative Online Inquiry
KO36617 MKS1 Knockout cell line (HCT 116) Human MKS1 1:2~1:4 Negative Online Inquiry
KO36618 MKS1 Knockout cell line (HEK293) Human MKS1 1:3~1:6 Negative Online Inquiry
KO36619 MKS1 Knockout cell line (A549) Human MKS1 1:3~1:4 Negative Online Inquiry

Background

MKS1 Gene Knockout Cell Lines are genetically engineered cellular models designed to study the role and function of the MKS1 gene, which is implicated in various biological processes, including cilia formation and related disorders. These cell lines have been meticulously developed using advanced CRISPR/Cas9 technology, enabling researchers to create precise and stable deletions of the MKS1 gene, allowing for the observation of phenotypic consequences and underlying molecular mechanisms.

The key function of the MKS1 Gene Knockout Cell Lines is their ability to facilitate the investigation of ciliary-related signaling pathways and their role in diseases such as Meckel syndrome and nephronophthisis. By studying these knockout cells, researchers can elucidate the contributions of the MKS1 gene to cellular processes such as cell cycle regulation, protein localization, and the coordination of tissue homeostasis, ultimately enhancing the understanding of ciliopathies.

In terms of scientific importance, these cell lines are invaluable in research and clinical settings, paving the way for potential therapeutic developments and advancing the understanding of genetic diseases. Their applications extend to drug discovery, genetic screening, and the identification of novel therapeutic targets, highlighting their significance in translational medicine.

What sets the MKS1 Gene Knockout Cell Lines apart from alternative models is their robust characterization and validation, ensuring consistent, reliable, and reproducible results. Furthermore, these knockout lines provide a definitive approach to investigating gene functions, facilitating experimental designs that require precise genetic manipulations.

For researchers and clinicians seeking to unravel the complexities of ciliogenesis and its related disorders, the MKS1 Gene Knockout Cell Lines offer a powerful tool to advance their investigations. They embody a unique value proposition by allowing the exploration of gene functions in an accessible manner that supersedes traditional models.

At our company, we pride ourselves on our expertise in developing high-quality biological products backed by cutting-edge technology and rigorous validation processes. With the MKS1 Gene Knockout Cell Lines, we are committed to supporting the scientific community in their quest for innovative solutions to challenging biological questions.

Please note that all services are for research use only. Not intended for any clinical use.

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