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MKRN1 Knockout Cell Lines

Gene: MKRN1

Official Full Name: makorin ring finger protein 1provided by HGNC

Gene Summary: This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29065 MKRN1 Knockout cell line (HeLa) Human MKRN1 1:3~1:6 Negative Online Inquiry
KO29066 MKRN1 Knockout cell line (HCT 116) Human MKRN1 1:2~1:4 Negative Online Inquiry
KO29067 MKRN1 Knockout cell line (HEK293) Human MKRN1 1:3~1:6 Negative Online Inquiry
KO29068 MKRN1 Knockout cell line (A549) Human MKRN1 1:3~1:4 Negative Online Inquiry

Background

MKRN1 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate in-depth studies of the MKRN1 gene's function, regulation, and implications in various biological processes. These cell lines are created using advanced CRISPR-Cas9 gene-editing technology to induce targeted mutations, effectively disabling the MKRN1 gene. This allows researchers to observe phenotypic changes and elucidate the role of MKRN1 in cellular mechanisms such as proliferation, apoptosis, and differentiation.

The key function of MKRN1 involves regulating gene expression and ubiquitination processes, which are essential for maintaining cellular homeostasis. By utilizing these knockout cell lines, scientists can investigate the gene's impact on oncogenesis, metabolic pathways, and its interactions with other molecular players. This is particularly valuable in cancer research, where understanding the nuances of gene regulation can lead to new therapeutic avenues.

The scientific importance of MKRN1 Gene Knockout Cell Lines is underscored by their applicability in both fundamental research and translational studies. They provide a reliable platform for high-throughput screening of drug candidates targeting associated pathways, as well as for evaluating the functional consequences of gene knockout on cellular behavior.

Compared to traditional methods of gene manipulation that often yield inconsistent results, MKRN1 Gene Knockout Cell Lines assure precision and reproducibility. These models not only save time in experimental setups but also enhance the accuracy of biological assays, making them an indispensable tool for researchers and clinicians alike.

For researchers and clinicians focused on gene function, cancer biology, and therapeutic development, these knockout cell lines represent a robust solution to uncovering the mysteries of MKRN1. Our company's commitment to providing high-quality, scientifically validated cell lines ensures that you receive products backed by expertise and innovation in genetic research. We understand the critical role that reliable models play in advancing science, and we are dedicated to supporting your research with our advanced product offerings.

Please note that all services are for research use only. Not intended for any clinical use.

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