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MINPP1 Knockout Cell Lines

Gene: MINPP1

Official Full Name: multiple inositol-polyphosphate phosphatase 1provided by HGNC

Gene Summary: This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33100 MINPP1 Knockout cell line (HeLa) Human MINPP1 1:3~1:6 Negative Online Inquiry
KO33101 MINPP1 Knockout cell line (HCT 116) Human MINPP1 1:2~1:4 Negative Online Inquiry
KO33102 MINPP1 Knockout cell line (HEK293) Human MINPP1 1:3~1:6 Negative Online Inquiry
KO33103 MINPP1 Knockout cell line (A549) Human MINPP1 1:3~1:4 Negative Online Inquiry

Background

MINPP1 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the MINPP1 (Multiple Inositol Polyphosphate Phosphatase 1) gene, which is crucial for the metabolic regulation of inositol phosphates. By creating a knockout of the MINPP1 gene, these cell lines enable researchers to explore the physiological role of this gene in cellular signaling and metabolic pathways, providing insights into various biological processes.

The primary function of these cell lines revolves around allowing for the assessment of cellular responses to inositol phosphate intermediates. Through the complete loss of MINPP1 activity, researchers can investigate downstream effects on phosphoinositide metabolism, calcium signaling, and related intracellular responses. The use of CRISPR/Cas9 technology in creating these knockout lines ensures high specificity and efficiency, significantly improving the reliability of experimental outcomes.

The scientific importance of MINPP1 Gene Knockout Cell Lines is underscored by their utility in research areas including cancer biology, neurobiology, and metabolic disorders. Understanding the function of MINPP1 offers valuable insights into its role as a potential therapeutic target, positioning it at the forefront of research aimed at developing novel treatments.

What sets these knockout cell lines apart from alternatives is their reliable consistency and reproducibility in experimental setups, which is critical for generating valid data. Additionally, they provide a platform for drug screening and biomarker discovery by allowing researchers to observe unregulated cellular behaviors that may emerge from the absence of MINPP1.

For researchers and clinicians, the MINPP1 Gene Knockout Cell Lines represent an invaluable tool for advancing our understanding of cellular mechanisms and potential therapeutic interventions. By opting for this product, users gain a scientific advantage in accelerating their research and potentially discovering breakthrough solutions in the field of molecular biology.

Our company is dedicated to delivering high-quality biological products and resources that empower scientists and clinicians in their quests for innovation. With expertise in gene editing technologies and a commitment to providing exceptional customer support, we ensure that our clients have the tools they need for their groundbreaking research.

Please note that all services are for research use only. Not intended for any clinical use.

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