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MEGF8 Knockout Cell Lines

Gene: MEGF8

Official Full Name: multiple EGF like domains 8provided by HGNC

Gene Summary: The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10033 MEGF8 Knockout cell line (HeLa) Human MEGF8 1:3~1:6 Negative Online Inquiry
KO10034 MEGF8 Knockout cell line (HCT 116) Human MEGF8 1:2~1:4 Negative Online Inquiry
KO10035 MEGF8 Knockout cell line (HEK293) Human MEGF8 1:3~1:6 Negative Online Inquiry
KO10036 MEGF8 Knockout cell line (A549) Human MEGF8 1:3~1:4 Negative Online Inquiry

Background

MEGF8 Gene Knockout Cell Lines are specialized cellular models engineered to specifically disable the MEGF8 gene, which plays a crucial role in cellular signaling, development, and interaction with other cells. This product offers scientists a powerful tool for investigating the gene's function and its implications for various biological processes.

These cell lines operate through the precise knockout mechanism facilitated by CRISPR/Cas9 technology, which allows for the targeted alteration of the genomic sequence. The loss of MEGF8 expression can lead to profound phenotypic changes, which can be then analyzed to elucidate its role in cellular adhesion, growth, and differentiation. By utilizing these cell lines, researchers can explore pathways relevant to developmental biology and human diseases, including neurodevelopmental disorders and cancers.

The scientific importance of MEGF8 Gene Knockout Cell Lines lies in their ability to provide insights into complex biological systems and the underlying mechanisms that drive various pathologies. Their applications extend to fundamental research, enabling the study of gene interactions and the downstream effects of gene alteration, as well as potential therapeutic targets in clinical settings.

Compared to alternative models, such as conventional wild-type cell lines or overexpression systems, MEGF8 Gene Knockout Cell Lines offer a more authentic representation of the gene's function by directly disabling its expression. This specificity allows for clearer interpretations of results, making research findings more relevant and applicable to real-world scenarios. Additionally, these knockout models ensure reproducibility and efficiency, ultimately saving time and resources for research teams.

For researchers and clinicians dedicated to advancing our understanding of genetic contribution to disease, these cell lines stand as invaluable resources, bridging the gap between basic research and practical applications. Our company is committed to providing high-quality biological products backed by comprehensive research and development. Recognized for our expertise and innovation in genetic engineering, we offer high-performance models that empower the scientific community to accelerate their discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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