Gene: MARCHF1
Official Full Name: membrane associated ring-CH-type finger 1provided by HGNC
Gene Summary: MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16335 | MARCHF1 Knockout cell line (HeLa) | Human | MARCHF1 | 1:3~1:6 | Negative | Online Inquiry |
KO16336 | MARCHF1 Knockout cell line (HCT 116) | Human | MARCHF1 | 1:2~1:4 | Negative | Online Inquiry |
KO16337 | MARCHF1 Knockout cell line (HEK293) | Human | MARCHF1 | 1:3~1:6 | Negative | Online Inquiry |
KO16338 | MARCHF1 Knockout cell line (A549) | Human | MARCHF1 | 1:3~1:4 | Negative | Online Inquiry |
MARCHF1 Gene Knockout Cell Lines are genetically altered cellular models specifically engineered to disrupt the MARCHF1 gene, a critical regulator of immune responses and signaling pathways. These cell lines serve as invaluable tools for researchers aiming to elucidate the functions of MARCHF1 in cellular physiology, particularly in the context of immune modulation, apoptosis, and viral pathogenesis.
The mechanisms behind the efficacy of these knockout cell lines involve the complete absence of the MARCHF1 protein, allowing scientists to investigate its role in various biological processes and to study how the loss of this gene affects cellular behavior, such as cytokine production and receptor signaling. By utilizing these cell lines, researchers can generate insights into the consequences of MARCHF1 deficiencies, leading to a better understanding of several immune-related diseases and therapeutic interventions.
The scientific importance of MARCHF1 Gene Knockout Cell Lines lies in their wide-ranging applications in both basic and applied research settings. They provide a platform for drug discovery, allowing for the assessment of therapeutic efficacy in conditions where MARCHF1 may play a pivotal role, such as autoimmune diseases and cancer. Additionally, these cell lines facilitate advancements in cell therapy and regenerative medicine by contributing to the knowledge required for developing targeted therapies.
What sets MARCHF1 Gene Knockout Cell Lines apart from traditional cellular models is their specificity and the robustness of their genetic modification, ensuring reliable reproducibility in experimental outcomes. This precision allows researchers to save time and resources while enhancing the accuracy of their findings compared to standard cell lines that may carry unmodified genes.
In conclusion, MARCHF1 Gene Knockout Cell Lines represent a significant advancement in the field of cellular and molecular biology, enabling researchers and clinicians to explore the functional dynamics of gene regulation with high fidelity. With years of expertise in producing high-quality biological reagents, our company is committed to providing innovative solutions to enhance research efficacy, speed up discovery processes, and ultimately contribute to the advancement of health sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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