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MAPK8IP3 Knockout Cell Lines

Gene: MAPK8IP3

Official Full Name: mitogen-activated protein kinase 8 interacting protein 3provided by HGNC

Gene Summary: The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10635 MAPK8IP3 Knockout cell line (HeLa) Human MAPK8IP3 1:3~1:6 Negative Online Inquiry
KO10636 MAPK8IP3 Knockout cell line (HCT 116) Human MAPK8IP3 1:2~1:4 Negative Online Inquiry
KO10637 MAPK8IP3 Knockout cell line (HEK293) Human MAPK8IP3 1:3~1:6 Negative Online Inquiry
KO10638 MAPK8IP3 Knockout cell line (A549) Human MAPK8IP3 1:3~1:4 Negative Online Inquiry

Background

MAPK8IP3 Gene Knockout Cell Lines are specialized cellular models designed to study the functional consequences of the MAPK8IP3 gene, which encodes the mitogen-activated protein kinase 8 interacting protein 3. These engineered cell lines have been generated through advanced CRISPR-Cas9 gene-editing technology, allowing for the precise deletion of the MAPK8IP3 gene to elucidate its role in cellular signaling pathways. By knocking out this gene, researchers can investigate the downstream effects on MAPK pathway activation, cellular proliferation, apoptosis, and various stress responses.

The primary function of these cell lines is to enable detailed analysis of MAPK8IP3's involvement in critical biological processes. Through the loss of MAPK8IP3, researchers can dissect aberrant signaling cascades that may lead to various diseases, including cancer and neurological disorders. Understanding these pathways is crucial, as it can reveal potential therapeutic targets and strategies for intervention.

In terms of scientific importance, MAPK8IP3 Gene Knockout Cell Lines serve as pivotal tools in both basic and translational research settings. Their ability to mimic specific disease conditions facilitates drug discovery and testing, enabling researchers to screen for compounds that can modulate MAPK pathways, thus contributing to the therapeutic arsenal against MAPK-related diseases.

A key advantage of our MAPK8IP3 Gene Knockout Cell Lines is their high specificity and reproducibility compared to traditional knockout methods, which often yield incomplete gene disruption. Additionally, our cell lines come with extensive characterization data, providing insight into cellular behaviors post-knockout, which is often lacking in alternative offerings. This consistency not only enhances the reliability of experimental results but also aids researchers in drawing meaningful conclusions.

Ultimately, these cell lines are invaluable for researchers and clinicians alike, offering a cost-effective and efficient means to explore the complexities of MAPK8IP3 signaling. With our company's expertise in genetic engineering and commitment to high-quality products, we provide researchers with essential tools to advance their investigations, making significant contributions to scientific knowledge and potential therapeutic breakthroughs in disease management.

Please note that all services are for research use only. Not intended for any clinical use.

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