Gene: MAP4K2
Official Full Name: mitogen-activated protein kinase kinase kinase kinase 2provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05643 | MAP4K2 Knockout cell line (HeLa) | Human | MAP4K2 | 1:3~1:6 | Negative | Online Inquiry |
KO05644 | MAP4K2 Knockout cell line (HCT 116) | Human | MAP4K2 | 1:2~1:4 | Negative | Online Inquiry |
KO05645 | MAP4K2 Knockout cell line (HEK293) | Human | MAP4K2 | 1:3~1:6 | Negative | Online Inquiry |
KO05646 | MAP4K2 Knockout cell line (A549) | Human | MAP4K2 | 1:3~1:4 | Negative | Online Inquiry |
MAP4K2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to study the function and role of the MAP4K2 gene, which encodes a serine/threonine kinase involved in various cellular processes, including signal transduction and cell proliferation. These knockout cell lines have had the MAP4K2 gene disrupted, allowing researchers to observe the effects of its absence on cellular mechanisms and pathways.
The primary function of the MAP4K2 gene is to modulate several signaling cascades, including those linked to the MAPK/ERK pathway, which plays a crucial role in cell division, differentiation, and response to external stimuli. By utilizing these knockout cell lines, researchers can investigate the downstream effects of MAP4K2 loss, providing valuable insights into diseases associated with aberrant kinase activity, such as cancer and neurodegenerative disorders.
In research and clinical settings, MAP4K2 knockout cell lines are essential tools for elucidating gene function and investigating therapeutic targets. Their application extends to drug discovery and development as they allow for the evaluation of potential compounds that might negate or mimic MAP4K2 activity, offering a new avenue for therapeutic intervention.
Unlike conventional wild-type cell lines, MAP4K2 knockout cell lines provide a unique perspective on the specific contributions of the MAP4K2 gene, allowing for more precise experimental outcomes. They reduce variability and enhance reproducibility in experiments focused on cellular signaling mechanisms.
For researchers and clinicians aiming to explore the intricate roles of kinases in cellular processes, these knockout models offer unparalleled advantages in understanding the functional consequences of gene deletion.
Our company specializes in creating advanced biological models, including these MAP4K2 knockout cell lines, backed by a team of experts dedicated to supporting groundbreaking research across various fields. Our commitment to quality and innovation enables scientists to unlock new insights into biological functions and disease mechanisms.
Please note that all services are for research use only. Not intended for any clinical use.
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