Gene: MAP4
Official Full Name: microtubule associated protein 4provided by HGNC
Gene Summary: The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36709 | MAP4 Knockout cell line (HeLa) | Human | MAP4 | 1:3~1:6 | Negative | Online Inquiry |
KO36710 | MAP4 Knockout cell line (HCT 116) | Human | MAP4 | 1:2~1:4 | Negative | Online Inquiry |
KO36711 | MAP4 Knockout cell line (HEK293) | Human | MAP4 | 1:3~1:6 | Negative | Online Inquiry |
KO36712 | MAP4 Knockout cell line (A549) | Human | MAP4 | 1:3~1:4 | Negative | Online Inquiry |
MAP4 Gene Knockout Cell Lines are expertly engineered cellular models that facilitate the study of the microtubule-associated protein 4 (MAP4) gene by providing a platform to investigate its function, regulation, and involvement in various biological processes. The knockout process effectively eliminates the expression of the MAP4 gene, allowing for the detailed assessment of its contributions to cellular behavior, including mitosis, intracellular transport, and neuronal structure and function.
These cell lines utilize advanced CRISPR-Cas9 gene-editing technology to create precise alterations in the genomic sequence, ensuring a high degree of specificity and efficiency in gene disruption. By effectively silencing MAP4, researchers can elucidate the pathways and interactions influenced by this protein, making significant advances in understanding its role in neurodevelopmental disorders, cancer biology, and neurodegenerative diseases.
The scientific importance of MAP4 Gene Knockout Cell Lines cannot be overstated, as they serve as pivotal tools in both basic and applied research settings. These models allow for novel high-throughput screening of potential therapeutic compounds, thereby accelerating drug discovery and development processes. Their application extends beyond academic laboratories, offering significant utility in pharmaceutical and biotechnology environments striving for breakthroughs in treatment modalities.
Compared to traditional RNA interference techniques or less specific genetic modifications, MAP4 Gene Knockout Cell Lines offer enhanced precision and stability in gene expression alteration, leading to more reliable experimental outcomes. This specificity allows researchers to generate unequivocal insights into gene function without the confounding effects often seen with other gene modulation strategies.
For researchers and clinicians, the value of these cell lines lies in their potential to uncover critical biological mechanisms that inform both the development of novel therapeutics and the advancement of personalized medicine approaches. With over a decade of expertise in genetic engineering and cellular model development, our company is committed to providing high-quality, ready-to-use MAP4 Gene Knockout Cell Lines, empowering the scientific community to push the boundaries of molecular and cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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