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MAP3K13 Knockout Cell Lines

Gene: MAP3K13

Official Full Name: mitogen-activated protein kinase kinase kinase 13provided by HGNC

Gene Summary: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10698 MAP3K13 Knockout cell line (HeLa) Human MAP3K13 1:3~1:6 Negative Online Inquiry
KO10699 MAP3K13 Knockout cell line (HCT 116) Human MAP3K13 1:2~1:4 Negative Online Inquiry
KO10700 MAP3K13 Knockout cell line (HEK293) Human MAP3K13 1:3~1:6 Negative Online Inquiry
KO10701 MAP3K13 Knockout cell line (A549) Human MAP3K13 1:3~1:4 Negative Online Inquiry

Background

MAP3K13 Gene Knockout Cell Lines represent a pivotal advancement in the realm of cellular biology and genetic research. These cell lines are engineered to have a knockout of the MAP3K13 gene, a critical component within the mitogen-activated protein kinase (MAPK) signaling pathway, which is involved in various cellular processes including inflammation, apoptosis, and differentiation. By specifically targeting and deactivating this gene, researchers can elucidate the biological functions mediated by MAP3K13, providing insights into its roles in health and disease.

The key functions of MAP3K13 involve its contribution to stress responses and cellular survival mechanisms, particularly in immune cells. By using these knockout cell lines, researchers can study the downstream effects of MAP3K13 inhibition, facilitating a comprehensive understanding of related signaling cascades, such as the NF-kB pathway and its implications in diseases like cancer and autoimmune disorders. The availability of these cell lines in both academic and clinical settings allows for a systematic approach to drug testing, gene therapy development, and the assessment of novel therapeutic targets.

MAP3K13 Gene Knockout Cell Lines offer significant advantages over traditional cell models, including a higher specificity of gene disruption and the capacity for reproducible results, thus minimizing variability. Unlike other models that may utilize pharmacological inhibition, these genetically modified lines provide a clearer cause-and-effect relationship between gene function and cellular phenotype, enhancing research accuracy.

Researchers and clinicians can benefit immensely from utilizing these knockout cell lines, as they facilitate the investigation of complex biological questions and therapeutic strategies. The ability to perform in-depth studies on disease mechanisms and treatment responses makes them invaluable tools in the quest for innovative healthcare solutions.

Our company is dedicated to advancing scientific understanding and research efficiency through high-quality biological products. With our expertise in gene editing technologies and the provision of customized cell lines, we are committed to supporting the scientific community in achieving groundbreaking discoveries across various fields of study.

Please note that all services are for research use only. Not intended for any clinical use.

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