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MAN2A1 Knockout Cell Lines

Gene: MAN2A1

Official Full Name: mannosidase alpha class 2A member 1provided by HGNC

Gene Summary: This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05701 MAN2A1 Knockout cell line (HeLa) Human MAN2A1 1:3~1:6 Negative Online Inquiry
KO05702 MAN2A1 Knockout cell line (HCT 116) Human MAN2A1 1:2~1:4 Negative Online Inquiry
KO05703 MAN2A1 Knockout cell line (HEK293) Human MAN2A1 1:3~1:6 Negative Online Inquiry
KO05704 MAN2A1 Knockout cell line (A549) Human MAN2A1 1:3~1:4 Negative Online Inquiry

Background

MAN2A1 Gene Knockout Cell Lines represent a powerful tool in genetic research, specifically designed to study the function and implications of the MAN2A1 gene, known for its role in the processing of N-glycans. These cell lines have been meticulously engineered using CRISPR/Cas9 technology to produce a targeted knockout of the MAN2A1 gene, allowing researchers to investigate the biological consequences of its absence in cellular processes related to glycoprotein maturation, immune response modulation, and disease pathogenesis.

The key function of these knockout cell lines lies in their ability to provide a controlled system for assessing the phenotypic and biochemical alterations resulting from the loss of MAN2A1. By disrupting the normal pathway of N-glycan processing, researchers can elucidate the gene's role in crucial cellular functions, such as cell signaling and adhesion. Furthermore, the knockout model supports the exploration of potential therapeutic interventions for diseases where glycosylation patterns are altered, such as certain cancers and congenital disorders.

The scientific importance of MAN2A1 Gene Knockout Cell Lines is underscored by their diverse applications in both fundamental research and clinical settings. They are invaluable for drug discovery, allowing for high-throughput screening of compounds that target glycosylation pathways. Additionally, they serve as a model for studying the pathological mechanisms underlying glycosylation-related diseases, providing insights that can drive innovation in biotherapeutic developments.

What sets these cell lines apart from alternatives is their precision and reliability, achieved through rigorous validation processes that ensure consistency across experiments. This makes them an exceptional choice for laboratories seeking reproducible and interpretable results. Researchers and clinicians can benefit from their straightforward integration into existing workflows, facilitating enhanced productivity and advancing scientific inquiry.

In conclusion, these MAN2A1 Gene Knockout Cell Lines embody our commitment to providing cutting-edge biological tools tailored to the needs of the research community. Our expertise in genetic engineering and cellular biology ensures that we deliver high-quality products that empower scientific advancement and contribute to breakthroughs in understanding complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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