Gene: LPIN1
Official Full Name: lipin 1provided by HGNC
Gene Summary: This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00054 | Lpin1 gRNA1 KO plasmid | Lpin1 | $850 | |||
GP01564 | Lpin1 gRNA2 KO plasmid | Lpin1 | $850 |
LPIN1 Gene Knockout Cell Lines are genetically modified cell models characterized by the inactivation of the LPIN1 gene, which encodes the enzyme lipin-1. This product serves as a critical tool for researchers studying lipid metabolism, adipose tissue biology, and cellular signaling pathways. By disrupting the LPIN1 gene, these cell lines enable scientists to investigate the physiological roles and molecular mechanisms related to lipin-1, including its involvement in fat storage, insulin sensitivity, and overall energy homeostasis.
The main function of LPIN1 Gene Knockout Cell Lines is to provide a platform that recapitulates the lipin-1 deficiency observed in various metabolic disorders. By understanding the changes in cellular processes that occur in the absence of lipin-1, researchers can elucidate its role in diseases such as obesity, diabetes, and cardiovascular conditions. The experimental models facilitate comprehensive analyses, such as gene expression profiling, cellular metabolism assessments, and lipidomic studies, thereby generating invaluable insights into the pathophysiology of metabolic diseases.
The scientific importance of these cell lines lies in their versatility and applicability in fundamental and translational research. They can be employed in drug discovery efforts, as well as in identifying new therapeutic targets for metabolic syndrome-related conditions. Compared to other genetic modification techniques, such as transient transfection or viral-mediated gene knockdowns, our LPIN1 Gene Knockout Cell Lines provide a stable and consistent genetic background, ensuring replicability across experiments and enhancing the reliability of results.
For researchers and clinicians, the unique advantage of using LPIN1 Gene Knockout Cell Lines is the ability to model human pathophysiological conditions more accurately. This not only facilitates a deeper understanding of disease mechanisms but also accelerates the development of targeted interventions. In addition, our cell lines are validated for performance and suitability across various experimental contexts, adding an extra layer of confidence in their use.
At our company, we pride ourselves on our commitment to advancing scientific research through high-quality biological products. Our expertise in genetic engineering and cell line development ensures that researchers have access to reliable models that support innovation and discovery in the rapidly evolving field of metabolic research.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.