Gene: LZTFL1
Official Full Name: leucine zipper transcription factor like 1provided by HGNC
Gene Summary: This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. [provided by RefSeq, Aug 2020]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21600 | LZTFL1 Knockout cell line (HeLa) | Human | LZTFL1 | 1:3~1:6 | Negative | Online Inquiry |
KO21601 | LZTFL1 Knockout cell line (HCT 116) | Human | LZTFL1 | 1:2~1:4 | Negative | Online Inquiry |
KO21602 | LZTFL1 Knockout cell line (HEK293) | Human | LZTFL1 | 1:3~1:6 | Negative | Online Inquiry |
KO21603 | LZTFL1 Knockout cell line (A549) | Human | LZTFL1 | 1:3~1:4 | Negative | Online Inquiry |
LZTFL1 Gene Knockout Cell Lines are specifically engineered cellular models that allow researchers to investigate the biological functions of the LZTFL1 gene through the loss of its normal function. Utilizing state-of-the-art CRISPR-Cas9 gene-editing technology, these cell lines provide a reliable platform for studying the gene's role in various physiological and pathological processes, including its implications in cancer biology and other diseases associated with altered cellular growth and differentiation.
The primary function of LZTFL1 includes involvement in cellular signaling pathways and the regulation of cellular processes such as apoptosis and proliferation. In these knockout cell lines, the absence of LZTFL1 allows for detailed investigations into its regulatory effects, providing insights into cellular responses under both normal and stress conditions. By observing phenotypic changes, researchers can elucidate the gene's contributions to disease mechanisms, paving the way for potential therapeutic targeting.
The scientific importance of LZTFL1 Gene Knockout Cell Lines extends beyond basic research; they serve as invaluable tools in drug discovery, biomarker identification, and understanding resistance mechanisms in cancer treatment. Clinically, this knowledge can support the development of personalized medicine approaches, particularly in oncology, where insights into gene function can inform treatment plans based on individual genetic profiles.
Compared to conventional cell lines with intact LZTFL1 function, our knockout models stand out for their precision, reproducibility, and ability to mimic disease states more accurately. This specificity allows researchers to reduce confounding variables and focus on direct effects attributable to the LZTFL1 gene.
For researchers and clinicians alike, the LZTFL1 Gene Knockout Cell Lines offer an unprecedented opportunity to gain deeper insights into gene function and its implications in disease. By understanding the nuances of gene regulation and its biological consequences, these models enable advancements in therapeutic strategies and biomarker identification.
Our company specializes in providing high-quality genetic tools and cell lines to facilitate groundbreaking research. With expertise in gene editing and a commitment to scientific excellence, we are dedicated to supporting researchers in their quest to unlock the complexities of gene function and its relevance in human health.
Please note that all services are for research use only. Not intended for any clinical use.
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