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LRP8 Knockout Cell Lines

Gene: LRP8

Official Full Name: LDL receptor related protein 8provided by HGNC

Gene Summary: This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20661 LRP8 Knockout cell line (HeLa) Human LRP8 1:3~1:6 Negative Online Inquiry
KO20662 LRP8 Knockout cell line (HCT 116) Human LRP8 1:2~1:4 Negative Online Inquiry
KO20663 LRP8 Knockout cell line (HEK293) Human LRP8 1:3~1:6 Negative Online Inquiry
KO20664 LRP8 Knockout cell line (A549) Human LRP8 1:3~1:4 Negative Online Inquiry

Background

LRP8 Gene Knockout Cell Lines are genetically engineered cellular models designed specifically to facilitate the study of the Low-Density Lipoprotein Receptor-Related Protein 8 (LRP8). By leveraging the CRISPR/Cas9 gene-editing technology, these cell lines effectively knock out the LRP8 gene, enabling researchers to investigate the functional implications of LRP8's absence in various biological processes, including lipid metabolism, signal transduction, and cellular responses to environmental stimuli.

These cell lines serve as a valuable tool for elucidating the mechanistic pathways mediated by LRP8 in health and disease. The knockout of the LRP8 gene allows researchers to examine changes in cellular behavior, including alterations in growth, differentiation, and response to stimuli, which can inform various research initiatives, particularly in the fields of metabolic syndromes, neurobiology, and cancer research. Furthermore, these cell lines can be utilized in drug discovery pipelines to assess therapeutic strategies targeting LRP8 or its associated pathways.

What sets LRP8 Gene Knockout Cell Lines apart from alternatives is the precision and efficiency of gene editing provided by CRISPR/Cas9 technology, ensuring that the knockout is complete and reproducible, which is critical for generating reliable data. In addition, our cell lines are rigorously validated for stable expression and characterized for consistent performance in various assays, making them an excellent choice for both academic and pharmaceutical research settings.

Researchers and clinicians will appreciate the inherent value of LRP8 Gene Knockout Cell Lines as they pave the way for new insights into cellular function and disease mechanisms, ultimately guiding the development of innovative strategies in disease treatment and prevention. Our company specializes in providing expertly engineered biological products that empower scientific discovery, backed by a team of experienced scientists dedicated to supporting your research goals.

Please note that all services are for research use only. Not intended for any clinical use.

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