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LPCAT2 Knockout Cell Lines

Gene: LPCAT2

Official Full Name: lysophosphatidylcholine acyltransferase 2provided by HGNC

Gene Summary: This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16497 LPCAT2 Knockout cell line (HeLa) Human LPCAT2 1:3~1:6 Negative Online Inquiry
KO16498 LPCAT2 Knockout cell line (HCT 116) Human LPCAT2 1:2~1:4 Negative Online Inquiry
KO16499 LPCAT2 Knockout cell line (HEK293) Human LPCAT2 1:3~1:6 Negative Online Inquiry
KO16500 LPCAT2 Knockout cell line (A549) Human LPCAT2 1:3~1:4 Negative Online Inquiry

Background

LPCAT2 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to lack the lysophosphatidylcholine acyltransferase 2 (LPCAT2) gene. This critical enzyme plays a vital role in phospholipid metabolism by catalyzing the transfer of acyl groups to lysophosphatidylcholine, contributing to the synthesis of phosphatidylcholine, a major component of biological membranes. The knockout of LPCAT2 provides a powerful tool for researchers investigating lipid metabolism, cell signaling, and membrane dynamics.

The primary function of LPCAT2 knockout cell lines is to serve as a platform for elucidating the consequences of disrupted lipid biosynthesis and the resultant effects on cellular functions, such as proliferation, apoptosis, and metabolic regulation. Researchers can leverage these cell lines to study disease mechanisms linked to altered phospholipid profiles, including cancer, cardiovascular diseases, and metabolic syndromes.

The scientific importance of LPCAT2 knockout cell lines extends to both basic research and potential therapeutic applications. In research settings, these cell lines can be employed in drug discovery, disease modeling, and biomarker identification, enabling a better understanding of cellular responses to therapeutic agents or genetic perturbations. Clinically, insights derived from these models may inform the development of targeted therapies aimed at restoring lipid homeostasis.

One of the specific advantages of LPCAT2 gene knockout cell lines is their ability to facilitate high-throughput screening and functional assays that are not possible with traditional models. Compared to other cell lines, these engineered models provide a more relevant and precise representation of human pathophysiology, which enhances the predictive power of experimental outcomes.

For researchers and clinicians, the value of LPCAT2 knockout cell lines lies in their ability to generate reproducible, high-quality data that can lead to meaningful insights into complex biological systems. This is particularly crucial for those focusing on lipid-related diseases where conventional models may fall short. Our company, with its dedication to advancing biotechnology tools, is proud to offer LPCAT2 gene knockout cell lines that empower scientific discovery and innovation in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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