Gene: KREMEN2
Official Full Name: kringle containing transmembrane protein 2provided by HGNC
Gene Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16624 | KREMEN2 Knockout cell line (HeLa) | Human | KREMEN2 | 1:3~1:6 | Negative | Online Inquiry |
KO16625 | KREMEN2 Knockout cell line (HCT 116) | Human | KREMEN2 | 1:2~1:4 | Negative | Online Inquiry |
KO16626 | KREMEN2 Knockout cell line (HEK293) | Human | KREMEN2 | 1:3~1:6 | Negative | Online Inquiry |
KO16627 | KREMEN2 Knockout cell line (A549) | Human | KREMEN2 | 1:3~1:4 | Negative | Online Inquiry |
KREMEN2 Gene Knockout Cell Lines are specially engineered cellular models that lack the KREMEN2 gene, which encodes a protein integral to regulating the Wnt signaling pathway and influencing cellular processes such as proliferation, migration, and differentiation. These knockout cell lines provide researchers with a powerful tool to investigate the biological functions of KREMEN2, elucidating its role in various physiological and pathological contexts, including cancer, stem cell biology, and autoimmune disorders.
The key function of these cell lines lies in the absence of KREMEN2, allowing for the systematic study of the effects of this gene's loss on cellular behavior and signaling pathways. Researchers can utilize these knockout lines to perform loss-of-function studies, revealing fundamental insights into how KREMEN2 orchestrates cellular responses. These insights play a significant role in understanding developmental processes and disease mechanisms, making KREMEN2 Gene Knockout Cell Lines highly valuable for both fundamental research and potential therapeutic applications.
In terms of scientific importance, KREMEN2 has been implicated in several critical biological functions and diseases. By providing a means to deconstruct the molecular pathways mediated by KREMEN2, these cell lines serve as invaluable resources in discovery-driven research, enabling the identification of novel drug targets and therapeutic strategies.
Compared to alternatives like siRNA approaches or pharmacological inhibitors, which can offer only transient inhibition, KREMEN2 Gene Knockout Cell Lines present a stable and reproducible platform for in-depth analysis. Their robust phenotype and genetic consistency ensure data reliability, facilitating the comparative studies necessary to advance scientific knowledge.
For researchers and clinicians looking to explore the complexities of cellular signaling and gene function, KREMEN2 Gene Knockout Cell Lines deliver significant value. The insights gained from experiments utilizing these models can propel forward our understanding of disease and therapeutic development.
Our company specializes in delivering high-quality biological products tailored for cutting-edge research, demonstrating our commitment to advancing the scientific community's capabilities. With expertise in cell line development and gene editing technologies, we ensure our products meet rigorous standards, contributing meaningfully to scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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