ITPR1 Knockout Cell Lines

ITPR1 Gene Knockout Cell Lines are meticulously engineered cellular models that facilitate the study of inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) function and its physiological roles in various biological processes. By employing state-of-the-art CRISPR/Cas9 genome editing technology, these cell lines exhibit a targeted knockout of the ITPR1 gene, leading to the absence of functional ITPR1 protein. This strategic disruption allows researchers to unravel the signaling pathways regulated by ITPR1, which plays a crucial role in calcium homeostasis and intracellular signaling in response to extracellular stimuli.

The primary mechanism of action of ITPR1 involves the release of calcium from the endoplasmic reticulum into the cytoplasm upon binding of inositol trisphosphate (IP3). The absence of ITPR1 in these knockout cell lines provides a unique opportunity to study the ensuing physiological effects, such as alterations in cell proliferation, apoptosis, and muscle contraction. Moreover, this model is invaluable for understanding diseases linked to dysfunctional calcium signaling, including cardiac hypertrophy, neurodegeneration, and several types of cancer.

In comparison to traditional cell lines that express the ITPR1 gene, the ITPR1 Gene Knockout Cell Lines offer precise experimental control, allowing for consistent and reproducible results that can accelerate research timelines. The specificity of the knockout enables researchers to directly attribute findings to the loss of ITPR1 activity, minimizing confounding variables present in heterogenous cell populations.

For researchers and clinicians exploring pathophysiological mechanisms or developing therapeutic strategies targeting calcium signaling pathways, the ITPR1 Gene Knockout Cell Lines serve as an essential tool. By providing unparalleled insights into the biological role of ITPR1, these cell lines have the potential to drive advancements in drug discovery and therapeutic interventions.

Our company prides itself on its commitment to scientific innovation and quality, offering a range of precisely engineered biological products designed to meet the evolving needs of the research community. With our expertise in genetic engineering and cellular biology, we are dedicated to supporting your research endeavors with cutting-edge solutions that can lead to meaningful scientific breakthroughs.