Gene: ING3
Official Full Name: inhibitor of growth family member 3provided by HGNC
Gene Summary: The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21619 | ING3 Knockout cell line (HeLa) | Human | ING3 | 1:3~1:6 | Negative | Online Inquiry |
KO21620 | ING3 Knockout cell line (HCT 116) | Human | ING3 | 1:2~1:4 | Negative | Online Inquiry |
KO21621 | ING3 Knockout cell line (HEK293) | Human | ING3 | 1:3~1:6 | Negative | Online Inquiry |
ING3 Gene Knockout Cell Lines are advanced biological tools designed to facilitate studies on the ING3 (Inhibitor of Growth family member 3) gene, an essential regulator involved in various cellular processes such as cell cycle progression, apoptosis, and DNA damage response. These genetically modified cell lines have had the ING3 gene specifically disrupted to allow researchers to investigate its functional role in cellular behavior, signaling pathways, and disease states.
The primary function of ING3 Gene Knockout Cell Lines is to create a controlled environment for exploring the biological effects and mechanisms behind ING3 loss of function. By eliminating the ING3 gene, these cell lines serve as a valuable model to study the implications of ING3 deficiency on growth regulation, tumorigenesis, and sensitivity to therapeutics, providing insights into potential therapeutic targets. The knockout approach ensures that the study of ING3 remains isolated from the confounding effects of other genes, thus yielding more precise experimental outcomes.
Scientific applications of ING3 Gene Knockout Cell Lines range from basic research in cancer biology to translational studies aimed at developing new therapeutic strategies. The ability to understand how ING3 functions and its interaction with other molecular pathways is critical for advancing our knowledge of cancer progression and exploring the potential for targeted therapies.
One of the key advantages of using ING3 Gene Knockout Cell Lines is their specificity and reliability compared to other methods such as siRNA knockdown or CRISPR interference, which can have off-target effects or incomplete knockdown. These cell lines provide a stable genetic model that is ideal for rigorous scientific experimentation, ensuring that researchers obtain reproducible and relevant results.
In summary, the ING3 Gene Knockout Cell Lines stand out as an invaluable resource for researchers and clinicians seeking to delve into the intricate roles of the ING3 gene in cellular regulation and disease. Utilized by experts in the field, these cell lines allow for enhanced understanding and innovation in therapeutic research and development. Our company is dedicated to providing high-quality biological products, ensuring our clients have access to tools that enable groundbreaking discoveries in molecular and cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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