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IL4R Knockout Cell Lines

Gene: IL4R

Official Full Name: interleukin 4 receptorprovided by HGNC

Gene Summary: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00952 IL4R Knockout cell line (HeLa) Human IL4R 1:3~1:6 Negative Online Inquiry
KO11260 IL4R Knockout cell line (HCT 116) Human IL4R 1:2~1:4 Negative Online Inquiry
KO11261 IL4R Knockout cell line (HEK293) Human IL4R 1:3~1:6 Negative Online Inquiry
KO11262 IL4R Knockout cell line (A549) Human IL4R 1:3~1:4 Negative Online Inquiry

Background

IL4R Gene Knockout Cell Lines represent a groundbreaking advancement in the study of the interleukin-4 receptor (IL4R), which plays a pivotal role in regulating immune responses. These cell lines are engineered to exhibit a complete knockout of the IL4R gene, providing invaluable models for researchers exploring the pathways and mechanisms of immune function and related disorders.

The primary function of IL4R is to mediate the effects of interleukin-4 (IL-4), a cytokine that is crucial for Th2 immune responses, including differentiation and activation of immune cells. By eliminating IL4R expression, these knockout cell lines enable the investigation of IL-4 signaling pathways and their implications in diseases such as asthma, allergy, and certain types of cancer. Researchers can utilize these cell lines to elucidate the mechanisms of immune modulation, assess therapeutic targets, and develop novel interventions aimed at boosting or suppressing immune responses as needed.

The scientific importance of IL4R Gene Knockout Cell Lines extends to both fundamental research and clinical applications. In research settings, these cell lines allow for the assessment of IL4R's role in various cellular processes, including cell proliferation, apoptosis, and cytokine production. In clinical science, understanding these mechanisms can lead to the development of targeted therapies that enhance patient outcomes in immunologically relevant conditions.

One of the unique selling points of our IL4R Gene Knockout Cell Lines lies in their high specificity and reliability compared to alternative models, such as transient gene knockdowns or CRISPR-edited cell lines with incomplete knockouts. Our proprietary cell lines ensure consistency in experimental outcomes, reducing variability that can affect data interpretation. This reliability enhances the confidence researchers can place in their findings, making our product an excellent choice for both academic and pharmaceutical research.

For researchers and clinicians focused on the interconnectedness of the immune system and disease, these knockout cell lines provide a powerful tool to dissect complex biological interactions. The ability to study the absence of IL4R facilitates innovative strategies and approaches in immunotherapy and personalized medicine.

With a robust commitment to advancing scientific discovery, our company specializes in the development and commercialization of high-quality biological products. Our expertise ensures that the IL4R Gene Knockout Cell Lines are precision-engineered and validated for optimal performance, making them an indispensable resource for those in the biological research community.

Please note that all services are for research use only. Not intended for any clinical use.

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