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IL17RC Knockout Cell Lines

Gene: IL17RC

Official Full Name: interleukin 17 receptor Cprovided by HGNC

Gene Summary: This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24608 IL17RC Knockout cell line (HeLa) Human IL17RC 1:3~1:6 Negative Online Inquiry
KO24609 IL17RC Knockout cell line (HCT 116) Human IL17RC 1:2~1:4 Negative Online Inquiry
KO24610 IL17RC Knockout cell line (HEK293) Human IL17RC 1:3~1:6 Negative Online Inquiry
KO24611 IL17RC Knockout cell line (A549) Human IL17RC 1:3~1:4 Negative Online Inquiry

Background

IL17RC Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of interleukin-17 receptor C (IL17RC) and its associated signaling pathways. These knockout cell lines are engineered using gene editing techniques, such as CRISPR/Cas9, to inactivate the IL17RC gene, thereby eliminating the expression of the corresponding protein. This allows researchers to investigate the role of IL17RC in various biological processes, particularly in the context of immune responses and inflammatory diseases.

The primary function of IL17RC is to act as a receptor for interleukin-17 cytokines, which play a crucial role in mediating inflammatory responses. By utilizing these knockout cell lines, scientists can examine the downstream effects of IL17RC signaling, including its impact on cytokine production, chemokine release, and immune cell activation. This can be particularly valuable for understanding the mechanisms underlying various autoimmune conditions and chronic inflammatory diseases, such as psoriasis or rheumatoid arthritis.

The scientific importance of IL17RC Gene Knockout Cell Lines extends to both research and clinical applications. In a research setting, these models provide a powerful tool for elucidating the molecular mechanisms of IL17RC-mediated signaling, effectively advancing our understanding of immune regulation. Clinically, insights gained from these studies could pave the way for novel therapeutic strategies targeting IL17RC or its pathways, offering potential hope for patients suffering from IL-17 related disorders.

Compared to traditional cell lines, the IL17RC Gene Knockout Cell Lines provide distinct advantages, including the ability to study specific gene functions in isolation without the confounding effects of the receptor's expression. This specificity enhances the reliability of experimental outcomes, making the data more valuable to researchers seeking to develop targeted interventions.

The value of IL17RC Gene Knockout Cell Lines lies in their contribution to the growing body of knowledge surrounding immune system regulation and inflammation. Researchers, clinicians, and biopharmaceutical companies alike can benefit from these models as they embark on developing innovative strategies for managing complex diseases. Our company, with its commitment to high-quality biological products and expertise in gene editing technologies, is proud to offer these state-of-the-art cell lines that empower the scientific community in their quest for transformative discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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