Gene: IGFBP2
Official Full Name: insulin like growth factor binding protein 2provided by HGNC
Gene Summary: The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37093 | IGFBP2 Knockout cell line (HeLa) | Human | IGFBP2 | 1:3~1:6 | Negative | Online Inquiry |
KO37094 | IGFBP2 Knockout cell line (HCT 116) | Human | IGFBP2 | 1:2~1:4 | Negative | Online Inquiry |
KO37095 | IGFBP2 Knockout cell line (HEK293) | Human | IGFBP2 | 1:3~1:6 | Negative | Online Inquiry |
KO37096 | IGFBP2 Knockout cell line (A549) | Human | IGFBP2 | 1:3~1:4 | Negative | Online Inquiry |
IGFBP2 Gene Knockout Cell Lines are genetically engineered mammalian cell lines that have undergone targeted modification to disrupt the IGFBP2 (Insulin-like Growth Factor Binding Protein 2) gene. This product allows researchers to explore the physiological and pathological roles of IGFBP2 in various cellular contexts by providing a model system where the expression of this important regulatory protein is nullified.
The key function of IGFBP2 involves its role as a modulator of insulin-like growth factor (IGF) activity, impacting processes such as cell proliferation, differentiation, and apoptosis. By utilizing these knockout cell lines, researchers can investigate the downstream effects of IGFBP2 absence, unraveling its contributions to critical pathways in cancer biology, metabolic disorders, and aging. The mechanisms of action can be elucidated through comparative studies with wild-type cells, assessing how the loss of IGFBP2 influences IGF signaling, glucose homeostasis, and the overall cellular microenvironment.
In both research and clinical settings, the scientific significance of IGFBP2 Gene Knockout Cell Lines is profound, particularly for studies focusing on cancer treatment responses and metabolic condition assessments. Their applications extend to drug discovery, where understanding IGFBP2’s role could lead to novel therapeutic targets.
One of the unique advantages of our IGFBP2 Gene Knockout Cell Lines is their high specificity and reliability, enabling reproducible results that stand out among existing alternatives. These cell lines are optimized for robust growth and maintenance, providing researchers with ease of use in experimental setups. Additionally, they come with a validated background that ensures consistency in experimental conditions.
For scientists and clinicians, the value of IGFBP2 Gene Knockout Cell Lines lies in their ability to provide insights into the intricate biological functions of IGFBP2, ultimately advancing therapeutic strategies across various disease models. Coupled with our company’s extensive expertise in genetic engineering and cell line development, this product is positioned to support cutting-edge research, making it an indispensable tool for the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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