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HSF2 Knockout Cell Lines

Gene: HSF2

Official Full Name: heat shock transcription factor 2provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37176 HSF2 Knockout cell line (HeLa) Human HSF2 1:3~1:6 Negative Online Inquiry
KO37177 HSF2 Knockout cell line (HCT 116) Human HSF2 1:2~1:4 Negative Online Inquiry
KO37178 HSF2 Knockout cell line (HEK293) Human HSF2 1:3~1:6 Negative Online Inquiry
KO37179 HSF2 Knockout cell line (A549) Human HSF2 1:3~1:4 Negative Online Inquiry

Background

HSF2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the Heat Shock Factor 2 (HSF2) gene, which is crucial for the regulation of heat shock proteins involved in the cellular response to stress. These knockout cell lines serve as vital tools for investigating the role of HSF2 in various biological processes, including stress responses, protein folding, and cellular differentiation. By understanding the absence of HSF2 functionality, researchers can elucidate the pathways and mechanisms that depend on this transcription factor, providing insight into the broader physiological implications related to cellular homeostasis.

The primary function of HSF2 involves the orchestration of heat shock protein genes in response to thermal and oxidative stress. The knockout of HSF2 allows for the dissection of alternative stress response mechanisms and the assessment of the role these proteins play in disease models, such as cancer, neurodegeneration, and metabolic disorders. Consequently, these cell lines are invaluable in research settings where elucidating the gene's function can lead to breakthroughs in therapeutic strategies that target stress-related diseases.

HSF2 Gene Knockout Cell Lines offer the unique advantage of specificity, high reproducibility, and the potential for integrative approaches when combined with other genetic modifications. Unlike traditional methods that depend on transient knockdown techniques, the stable knockout allows researchers to utilize these cell lines over extended periods without variability, ensuring consistent experimental conditions. This reliability is invaluable in both basic research and pre-clinical studies.

For researchers and clinicians, these knockout cell lines facilitate a deeper understanding of protein homeostasis and stress response pathways, which are often dysregulated in numerous diseases. By utilizing HSF2 Gene Knockout Cell Lines, scientists can explore innovative approaches to develop targeted therapies and improve patient outcomes in stress-related disorders.

Our company prides itself on offering high-quality biological models that empower the scientific community. With extensive expertise in genetic engineering and a commitment to rigorous quality assurance, we ensure that our products, including the HSF2 Gene Knockout Cell Lines, meet the highest standards of accuracy and efficacy, making them an essential addition to any research portfolio.

Please note that all services are for research use only. Not intended for any clinical use.

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