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HOXA5 Knockout Cell Lines

Gene: HOXA5

Official Full Name: homeobox A5provided by HGNC

Gene Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37283 HOXA5 Knockout cell line (HeLa) Human HOXA5 1:3~1:6 Negative Online Inquiry
KO37284 HOXA5 Knockout cell line (HCT 116) Human HOXA5 1:2~1:4 Negative Online Inquiry
KO37285 HOXA5 Knockout cell line (HEK293) Human HOXA5 1:3~1:6 Negative Online Inquiry
KO37286 HOXA5 Knockout cell line (A549) Human HOXA5 1:3~1:4 Negative Online Inquiry

Background

HOXA5 Gene Knockout Cell Lines are specialized cellular models engineered to selectively disrupt the expression of the HOXA5 gene, a key transcription factor known for its critical role in developmental processes and tumorigenesis. These cell lines are utilized in research to elucidate the functional significance of HOXA5 in various biological contexts, including embryonic development, differentiation, and cancer biology.

The primary mechanism of these knockout cell lines involves the application of gene-editing technologies, such as CRISPR/Cas9, which create targeted mutations in the HOXA5 gene. As a result, researchers can observe changes in cellular behavior, gene expression patterns, and protein interactions, thereby gaining insights into the pathway dynamics associated with altered HOXA5 activity. This functionality is essential for understanding the broader implications of HOXA5 in diseases such as leukemia and breast cancer, where its dysregulation is frequently implicated.

In scientific and clinical settings, HOXA5 Gene Knockout Cell Lines serve as invaluable tools for studying the mechanistic pathways that govern cell proliferation, apoptosis, and differentiation. By allowing the detailed examination of HOXA5's role, these cell lines facilitate the development of innovative therapeutic strategies targeting HOXA5-related pathways.

One of the unique advantages of our HOXA5 Gene Knockout Cell Lines is their superior specificity and reliability compared to traditional knockout models. Unlike random mutagenesis or shRNA techniques, our CRISPR/Cas9-generated models provide precise and permanent gene disruption, ensuring that researchers can trust their experimental outcomes. Moreover, our cell lines are thoroughly validated, with consistent performance across multiple experiments.

For researchers and clinicians looking to advance their understanding of cancer biology and developmental processes, HOXA5 Gene Knockout Cell Lines represent a critical asset. Their precision and utility can significantly enhance experimental reproducibility and facilitate the translation of laboratory findings into potential therapeutic approaches.

With extensive expertise in cellular biology and gene editing technology, our company is committed to delivering high-quality biological products that empower researchers in their scientific pursuits. Our dedication to innovation and quality makes us a trusted partner in advancing biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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