Gene: HIC2
Official Full Name: HIC ZBTB transcriptional repressor 2provided by HGNC
Gene Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29847 | HIC2 Knockout cell line (HeLa) | Human | HIC2 | 1:3~1:6 | Negative | Online Inquiry |
KO29848 | HIC2 Knockout cell line (HCT 116) | Human | HIC2 | 1:2~1:4 | Negative | Online Inquiry |
KO29849 | HIC2 Knockout cell line (HEK293) | Human | HIC2 | 1:3~1:6 | Negative | Online Inquiry |
KO29850 | HIC2 Knockout cell line (A549) | Human | HIC2 | 1:3~1:4 | Negative | Online Inquiry |
HIC2 Gene Knockout Cell Lines are genetically engineered cellular models designed to study the functional role of the HIC2 gene, which is known to be involved in various biological processes, including cellular signaling and differentiation. These cell lines have undergone precise gene editing through CRISPR-Cas9 technology to create stable knockout models that lack functional HIC2 expression. This specificity allows researchers to investigate the downstream effects of HIC2 deficiency, thereby unraveling its contributions to normal physiology and disease states.
The key function of HIC2 Gene Knockout Cell Lines is to provide a platform for functional genomics research, enabling scientists to explore the gene's role in conditions such as cancer, neurodegenerative diseases, and developmental disorders. By utilizing these cell lines, researchers can perform assays to evaluate fundamental biological processes, such as cell proliferation, apoptosis, and gene expression changes, facilitating a deeper understanding of the HIC2 signaling pathways and their implications in pathophysiology.
The scientific importance of these knockout cell lines lies in their ability to serve as models for translational research, allowing investigations that could lead to biomarker discovery and potential therapeutic targets. In clinical settings, such models can contribute to the development of personalized medicine strategies by elucidating how variations in the HIC2 gene affect patient outcomes.
Compared to traditional methods of gene silencing, such as RNA interference, HIC2 Gene Knockout Cell Lines offer permanent and heritable gene disruption, ensuring consistent results across experiments. This genetic stability enhances the reliability of experimental data, making them a superior choice for long-term studies.
For researchers and clinicians alike, HIC2 Gene Knockout Cell Lines represent a critical resource for expanding knowledge in gene function and disease mechanisms. They are essential for anyone looking to innovate in the fields of genetics, oncology, or regenerative medicine, providing valuable insights that can lead to improved therapeutic strategies.
As a company dedicated to advancing biological research, we take pride in our expertise in cell line development, ensuring that our products meet the highest standards of quality and reproducibility. Our commitment to supporting the scientific community enables researchers to achieve their goals efficiently and effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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